| Literature DB >> 31451384 |
Mario Galgani1, Giuseppe Matarese2.
Abstract
Metabolic alterations leading to overactivation of nutrient-energy-sensing pathways have been linked to altered immunological self-tolerance. Now, Zhang and colleagues (Immunity, 2019) have identified a key role for high glucose consumption in exacerbating autoimmunity in mice via induction of T helper (Th)17 cells. This reveals a novel mechanism underlying effects of diet during autoimmunity development with major translational implications.Entities:
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Year: 2019 PMID： 31451384 DOI： 10.1016/j.molmed.2019.08.003
Source DB: PubMed Journal: Trends Mol Med ISSN： 1471-4914 Impact factor: 11.951