Ana C B Marini1, Gustavo D Pimentel2. 1. Clinical and Sports Nutrition Research Laboratory (Labince), Faculty of Nutrition, Federal University of Goias, Goiânia, GO, Brazil. 2. Clinical and Sports Nutrition Research Laboratory (Labince), Faculty of Nutrition, Federal University of Goias, Goiânia, GO, Brazil. Electronic address: gupimentel@yahoo.com.br.
Abstract
BACKGROUND & AIMS: In hemodialysis (HD) patients, malnutrition and sedentary habits increase physical disability that contributes the loss of skeletal muscle mass. This vicious cycle contributes to poor quality of life and premature death. Therefore, considering that body weight is an item from the Malnutrition Inflammation Score (MIS) questionnaire, we hypothesize that body weight is an anthropometric marker that is just as important as muscle strength measurements in predicting changes in MIS. Thus, our study aimed to evaluate if there is a correlation between body weight and muscle strength measurements with the MIS in HD patients. METHODS: A cross-sectional design study was conducted with patients who were enrolled at two HD clinics. Body weight (kg), height (m), body mass index (BMI-kg/m2); handgrip strength (HGS-kg) using a dynamometer, 1 repetition maximum (1RM) leg extension and MIS were used to present clinical history and physical examinations of the patient. RESULTS: From 60 patients, 12.6% (n = 21) had MIS≥6, classified as malnutrition. The patients studied had a median age of 39 (19-59) years and were mostly men (n = 41), who had, on average, the nutritional status for the eutrophic BMI (23.76 ± 5.31 kg/m2) and muscle strength of HGS 33.10 ± 10.17 kg on average, as well as1 RM leg extension 73.03 ± 27.34 kg. In addition, MIS was similarly correlated with body weight (r = -0.46; p = 0.0002), HGS (r = -0.44; p = 0.0004) and 1 RM leg extension (r = -0.49; p < 0.0001). CONCLUSIONS: Although, HGS and 1 RM leg extension were correlated with MIS, we found that body weight also was associated with MIS. Therefore, in clinical practice with the lack of equipment to measure muscle strength and inflammatory cytokines, a simple evaluation of body weight may be sufficient to predict malnutrition and MIS in HD patients.
BACKGROUND & AIMS: In hemodialysis (HD) patients, malnutrition and sedentary habits increase physical disability that contributes the loss of skeletal muscle mass. This vicious cycle contributes to poor quality of life and premature death. Therefore, considering that body weight is an item from the Malnutrition Inflammation Score (MIS) questionnaire, we hypothesize that body weight is an anthropometric marker that is just as important as muscle strength measurements in predicting changes in MIS. Thus, our study aimed to evaluate if there is a correlation between body weight and muscle strength measurements with the MIS in HDpatients. METHODS: A cross-sectional design study was conducted with patients who were enrolled at two HD clinics. Body weight (kg), height (m), body mass index (BMI-kg/m2); handgrip strength (HGS-kg) using a dynamometer, 1 repetition maximum (1RM) leg extension and MIS were used to present clinical history and physical examinations of the patient. RESULTS: From 60 patients, 12.6% (n = 21) had MIS≥6, classified as malnutrition. The patients studied had a median age of 39 (19-59) years and were mostly men (n = 41), who had, on average, the nutritional status for the eutrophic BMI (23.76 ± 5.31 kg/m2) and muscle strength of HGS 33.10 ± 10.17 kg on average, as well as1 RM leg extension 73.03 ± 27.34 kg. In addition, MIS was similarly correlated with body weight (r = -0.46; p = 0.0002), HGS (r = -0.44; p = 0.0004) and 1 RM leg extension (r = -0.49; p < 0.0001). CONCLUSIONS: Although, HGS and 1 RM leg extension were correlated with MIS, we found that body weight also was associated with MIS. Therefore, in clinical practice with the lack of equipment to measure muscle strength and inflammatory cytokines, a simple evaluation of body weight may be sufficient to predict malnutrition and MIS in HDpatients.