Jing Zhu1, Wei Hu2, Yi Zhou3, Juan Qiao1, Xue Chang1, Zhu Tong1. 1. Xuzhou Oriental People's Hospital, Xuzhou 221004, Jiangsu, China. 2. Xuzhou Oriental People's Hospital, Xuzhou 221004, Jiangsu, China. Electronic address: huwei625@gmail.com. 3. Department of Neurobiology, Army Medical University, Chongqing 400038, China.
Abstract
BACKGROUND: To clarify the controversy regarding the relationship between serum high-sensitivity C-reactive protein (hs-CRP) levels and cognitive impairments in first-episode schizophrenic patients and examine whether hs-CRP is a potential objective biological indicator for evaluating cognitive impairment in first-episode schizophrenic patients. METHODS: Serum hs-CRP levels were measured in 58 first-episode schizophrenic patients and 31 healthy controls using immunofluorescence. The Brief Psychiatric Rating Scale (BPRS) and the P300 event-related potential were assessed. The relationship between serum hs-CRP levels and both BPRS scores and P300 were analyzed. RESULTS: Serum hs-CRP levels and BPRS scores were significantly higher in the study group than in the control group. The incubation period of P3 was longer, and the amplitude of P3 was larger in the study group than in the control group. Correlation analysis showed that in the study group, serum hs-CRP levels were positively correlated with BPRS total scores. Serum hs-CRP levels were also positively correlated with the incubation period of P3 and negatively correlated with P3 amplitudes. CONCLUSIONS: Serum hs-CRP levels were positively associated with cognitive impairment in first-episode schizophrenic patients and potentially represent an objective biological indicator for the rapid evaluation of cognitive impairment in first-episode schizophrenic patients.
BACKGROUND: To clarify the controversy regarding the relationship between serum high-sensitivity C-reactive protein (hs-CRP) levels and cognitive impairments in first-episode schizophrenicpatients and examine whether hs-CRP is a potential objective biological indicator for evaluating cognitive impairment in first-episode schizophrenicpatients. METHODS: Serum hs-CRP levels were measured in 58 first-episode schizophrenicpatients and 31 healthy controls using immunofluorescence. The Brief Psychiatric Rating Scale (BPRS) and the P300 event-related potential were assessed. The relationship between serum hs-CRP levels and both BPRS scores and P300 were analyzed. RESULTS: Serum hs-CRP levels and BPRS scores were significantly higher in the study group than in the control group. The incubation period of P3 was longer, and the amplitude of P3 was larger in the study group than in the control group. Correlation analysis showed that in the study group, serum hs-CRP levels were positively correlated with BPRS total scores. Serum hs-CRP levels were also positively correlated with the incubation period of P3 and negatively correlated with P3 amplitudes. CONCLUSIONS: Serum hs-CRP levels were positively associated with cognitive impairment in first-episode schizophrenicpatients and potentially represent an objective biological indicator for the rapid evaluation of cognitive impairment in first-episode schizophrenicpatients.