| Literature DB >> 31449863 |
Yalin Wang1, Xingming Ji1, Meilin Yan1, Xue Chen1, Mingzhu Kang2, Liping Teng1, Xiaotao Wu2, Jinghua Chen3, Chao Deng4.
Abstract
Polysaccharide (DIP) from Dictyophora indusiata has showed noteworthy anti-inflammatory activities. Given that the closely relationship between inflammation and ulcerative colitis, we speculated that DIP may alleviate ulcerative colitis. However, there was not any report about the effect of DIP on this disease. The purpose of this paper is to explore the protective effect and mechanism of DIP on DSS-induced colitis in C57BL/6 mice. The data indicated that DIP could improve DSS-induced colitis by restoring intestinal barrier function and regulating macrophage polarization. Its mechanism was found to be associated with decreased oxidative stresses and inflammation, suppressive key signal pathways related with colitis, improved the expression of tight junction proteins and down-regulated M1 macrophage polarization. The results suggested that DIP could be served as an agent for improving intestinal inflammation in functional foods or nutraceutical formulations.Entities:
Keywords: Anti-inflammatory activity; DSS-induced colitis; Dictyophora indusiata polysaccharide; Intestinal barrier function; Macrophage polarization
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Year: 2019 PMID： 31449863 DOI： 10.1016/j.ijbiomac.2019.08.198
Source DB: PubMed Journal: Int J Biol Macromol ISSN： 0141-8130 Impact factor: 6.953