Literature DB >> 3144806

Epithelial restitution in the large intestine of the rat following insult with bile salts.

D A Waller1, N W Thomas, T J Self.   

Abstract

In situ loops of large bowel of anaesthetised rats were used to observe epithelial restitution following surface desquamation using solutions of bile salts. The treatment induced complete surface desquamation but no disruption of the basal lamina. There was evidence of, cell migration at 30 min, and a complete surface epithelium two h post treatment. Neither a continuous contact between migrating cells and the basal lamina, nor a complete covering of secreted mucus, appeared necessary for epithelial restitution to occur.

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Year:  1988        PMID: 3144806     DOI: 10.1007/bf00749741

Source DB:  PubMed          Journal:  Virchows Arch A Pathol Anat Histopathol        ISSN: 0174-7398


  15 in total

1.  Role of mucus in the repair of gastric epithelial damage in the rat. Inhibition of epithelial recovery by mucolytic agents.

Authors:  J L Wallace; B J Whittle
Journal:  Gastroenterology       Date:  1986-09       Impact factor: 22.682

2.  Formation of a fibrin based gelatinous coat over repairing rat gastric epithelium after acute ethanol damage: interaction with adherent mucus.

Authors:  L A Sellers; A Allen; M K Bennett
Journal:  Gut       Date:  1987-07       Impact factor: 23.059

Review 3.  Basal lamina scaffold-anatomy and significance for maintenance of orderly tissue structure.

Authors:  R Vracko
Journal:  Am J Pathol       Date:  1974-11       Impact factor: 4.307

4.  Gastric mucosal resistance to a repeated ethanol insult.

Authors:  E R Lacy
Journal:  Scand J Gastroenterol Suppl       Date:  1985

5.  Effect of deoxycholate on the perfused rat colon. Scanning and transmission electron microscopic study of the morphological alterations occurring during the secretagogue action of deoxycholate.

Authors:  K J Goerg; W Specht; G Nell; W Rummel; L Schulz
Journal:  Digestion       Date:  1982       Impact factor: 3.216

6.  Effects of calcium and pH on the mucosal damage produced by deoxycholic acid in the rat colon.

Authors:  J J Rafter; V W Eng; R Furrer; A Medline; W R Bruce
Journal:  Gut       Date:  1986-11       Impact factor: 23.059

7.  The roles of ethanol and of acid in the production of gastric mucosal erosions in rats.

Authors:  G P Morris; J L Wallace
Journal:  Virchows Arch B Cell Pathol Incl Mol Pathol       Date:  1981

8.  Effects of acid on the basal lamina of the rat stomach and duodenum.

Authors:  B A Black; G P Morris; J L Wallace
Journal:  Virchows Arch B Cell Pathol Incl Mol Pathol       Date:  1985

9.  Morphology of rat gastric mucosal damage, defense, and restitution in the presence of luminal ethanol.

Authors:  S Ito; E R Lacy
Journal:  Gastroenterology       Date:  1985-01       Impact factor: 22.682

10.  Rapid repair of injured gastric mucosa.

Authors:  S Ito; E R Lacy; M J Rutten; J Critchlow; W Silen
Journal:  Scand J Gastroenterol Suppl       Date:  1984
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  6 in total

Review 1.  Healing the epithelium: solving the problem from two sides.

Authors:  D K Podolsky
Journal:  J Gastroenterol       Date:  1997-02       Impact factor: 7.527

2.  Acute epithelial injury in the rat small intestine in vivo is associated with expanded expression of transforming growth factor alpha and beta.

Authors:  A U Dignass; J L Stow; M W Babyatsky
Journal:  Gut       Date:  1996-05       Impact factor: 23.059

3.  Evaluation of mucosal damage and recovery in the gastrointestinal tract of rats by a penetration enhancer.

Authors:  Yogeeta Narkar; Ronald Burnette; Reiner Bleher; Ralph Albrecht; Angki Kandela; Joseph R Robinson
Journal:  Pharm Res       Date:  2007-12-27       Impact factor: 4.200

4.  Trefoil peptides promote epithelial migration through a transforming growth factor beta-independent pathway.

Authors:  A Dignass; K Lynch-Devaney; H Kindon; L Thim; D K Podolsky
Journal:  J Clin Invest       Date:  1994-07       Impact factor: 14.808

5.  One-dimensional elastic continuum model of enterocyte layer migration.

Authors:  Qi Mi; David Swigon; Béatrice Rivière; Selma Cetin; Yoram Vodovotz; David J Hackam
Journal:  Biophys J       Date:  2007-08-17       Impact factor: 4.033

6.  Inflammatory signals that regulate intestinal epithelial renewal, differentiation, migration and cell death: Implications for necrotizing enterocolitis.

Authors:  Jegen Kandasamy; Shehzad Huda; Namasivayam Ambalavanan; Tamas Jilling
Journal:  Pathophysiology       Date:  2014-02-16
  6 in total

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