L Zhao 1 , W W Chi 2 , H Cao 1 , W X Meng 1 , W N Cui 1 , B S Wang 1 Show Affiliations »
Abstract
Objective:The aim of this study is to explore the relative expression level of LINC00152 in laryngeal squamous cell carcinoma（LSCC） and its clinical significance. Method:The relative expression levels of LINC00152 in LSCC cell lines and 36 paired LSCC specimens were measured by qRT-PCR method. And the correlations between the expression level of LINC00152 and the clinical features derived from LSCC patients were analyzed and compared through the independent sample t-test. Result:The relative expression level of LINC00152 was over-expressed in LSCC cell lines and cancerous tissues than that in paired adjacent normal tissues, and the difference was statistically significant（P=0.006）. Even the associations between LINC00152 expression level and clinicopathological features（P=0.044 for clinical stage, P=0.032 for pathological differentiation degree） were significantly. Conclusion: LINC00152 is highly expressed in LSCC and it may become a new tumor marker for the diagnosis and prognosis of LSCC. Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.
Objective:The aim of this study is to explore the relative expression level of LINC00152 in laryngeal squamous cell carcinoma （LSCC） and its clinical significance. Method:The relative expression levels of LINC00152 in LSCC cell lines and 36 paired LSCC specimens were measured by qRT-PCR method. And the correlations between the expression level of LINC00152 and the clinical features derived from LSCC patients were analyzed and compared through the independent sample t-test. Result:The relative expression level of LINC00152 was over-expressed in LSCC cell lines and cancerous tissues than that in paired adjacent normal tissues, and the difference was statistically significant（P=0.006）. Even the associations between LINC00152 expression level and clinicopathological features（P=0.044 for clinical stage, P=0.032 for pathological differentiation degree） were significantly. Conclusion: LINC00152 is highly expressed in LSCC and it may become a new tumor marker for the diagnosis and prognosis of LSCC. Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.
Entities: Disease
Gene
Species
Keywords:
biomarker; LINC00152; laryngeal neoplasms; long non-coding RNA
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Year: 2019
PMID： 31446726 DOI： 10.13201/j.issn.1001-1781.2019.08.010
Source DB: PubMed Journal: Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi ISSN： 2096-7993