Blair Olson1, Wilson Vincent2, Jaimie P Meyer1,3, Trace Kershaw1, Kathleen J Sikkema4, Timothy G Heckman5, Nathan B Hansen6,7. 1. School of Public Health, Yale University, New Haven, CT, USA. 2. School and Department of Medicine, Center for AIDS Prevention Studies, University of California, San Francisco, San Francisco, CA, USA. 3. Department of Medicine, AIDS Program, Yale University School of Medicine, New Haven, CT, USA. 4. Department of Sociomedical Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA. 5. College of Public Health, University of Georgia, Athens, GA, USA. 6. College of Public Health, University of Georgia, Athens, GA, USA. nhansen@uga.edu. 7. Department of Health Promotion and Behavior, College of Public Health, University of Georgia, 131 Wright Hall, Health Sciences Campus, Athens, GA, 30602, USA. nhansen@uga.edu.
Abstract
PURPOSE: In the United States, approximately 45% of persons living with HIV (PLHIV) are ≥ 50 years of age. Many older PLHIV have multi-morbidities that complicate HIV infection and/or interfere with, or are exacerbated by, antiretroviral treatment. Physical health symptoms and psychiatric disorders, particularly depression, can worsen life quality in older PLHIV. METHODS: This study assessed associations among physical symptoms, indicators of HIV-related health status (i.e., time since diagnosis; ever diagnosed with AIDS; having attained viral suppression), depressive symptoms, and health-related quality of life (HRQoL) in older PLHIV. Regression analyses examined data from 296 PLHIV ≥ 50 years of age living in Cincinnati, OH, Columbus, OH, and New York City. RESULTS: Depressive symptoms and physical symptoms, particularly those related to appearance and sexual functioning, most strongly predicted HRQoL. Indicators of HIV health status did not significantly predict HRQoL. Depressive symptoms were a particularly robust predictor of HRQoL, even when accounting for physical health symptoms. CONCLUSION: Findings suggest that symptom management is critical to HRQoL in older PLHIV, and symptoms related to physical appearance and sexual functioning should not be overlooked in this growing population.
PURPOSE: In the United States, approximately 45% of persons living with HIV (PLHIV) are ≥ 50 years of age. Many older PLHIV have multi-morbidities that complicate HIV infection and/or interfere with, or are exacerbated by, antiretroviral treatment. Physical health symptoms and psychiatric disorders, particularly depression, can worsen life quality in older PLHIV. METHODS: This study assessed associations among physical symptoms, indicators of HIV-related health status (i.e., time since diagnosis; ever diagnosed with AIDS; having attained viral suppression), depressive symptoms, and health-related quality of life (HRQoL) in older PLHIV. Regression analyses examined data from 296 PLHIV ≥ 50 years of age living in Cincinnati, OH, Columbus, OH, and New York City. RESULTS: Depressive symptoms and physical symptoms, particularly those related to appearance and sexual functioning, most strongly predicted HRQoL. Indicators of HIV health status did not significantly predict HRQoL. Depressive symptoms were a particularly robust predictor of HRQoL, even when accounting for physical health symptoms. CONCLUSION: Findings suggest that symptom management is critical to HRQoL in older PLHIV, and symptoms related to physical appearance and sexual functioning should not be overlooked in this growing population.
Entities:
Keywords:
Aging; Depression; HIV/AIDS; Physical symptoms; Quality of life
Authors: David P Sheppard; Jennifer E Iudicello; Erin E Morgan; Rujvi Kamat; Lindsay R Clark; Gunes Avci; Mark W Bondi; Steven Paul Woods Journal: J Neurovirol Date: 2017-03-20 Impact factor: 2.643
Authors: I Marion de Boer-van der Kolk; Mirjam A G Sprangers; Jan M Prins; Colette Smit; Frank de Wolf; Pythia T Nieuwkerk Journal: Clin Infect Dis Date: 2010-01-15 Impact factor: 9.079
Authors: Alan T Rodriguez-Penney; Jennifer E Iudicello; Patricia K Riggs; Katie Doyle; Ronald J Ellis; Scott L Letendre; Igor Grant; Steven Paul Woods Journal: AIDS Patient Care STDS Date: 2013-01 Impact factor: 5.078
Authors: L S Briongos Figuero; P Bachiller Luque; T Palacios Martín; M González Sagrado; J M Eiros Bouza Journal: HIV Med Date: 2011-01 Impact factor: 3.180
Authors: Audrey L Khoury; Miriam C Morey; Tammy C Wong; Donna Lynn McNeil; Barlett Humphries; Katherine Frankey; Carl F Pieper; Charles B Hicks; Kim Huffman; Mehri S McKellar Journal: PLoS One Date: 2017-06-29 Impact factor: 3.240
Authors: Kelly Safreed-Harmon; Maria J Fuster-RuizdeApodaca; Marta Pastor de la Cal; Jeffrey V Lazarus Journal: Health Qual Life Outcomes Date: 2022-05-25 Impact factor: 3.077
Authors: Maria José Fuster-RuizdeApodaca; Kelly Safreed-Harmon; Marta Pastor de la Cal; Ana Laguia; Denise Naniche; Jeffrey V Lazarus Journal: Front Psychol Date: 2021-06-09
Authors: Ke Han; Shanshan Yang; Wangping Jia; Shengshu Wang; Yang Song; Wenzhe Cao; Jianwei Wang; Miao Liu; Yao He Journal: Front Public Health Date: 2020-10-30
Authors: Jeffrey V Lazarus; Kelly Safreed-Harmon; Adeeba Kamarulzaman; Jane Anderson; Ricardo Baptista Leite; Georg Behrens; Linda-Gail Bekker; Sanjay Bhagani; Darren Brown; Graham Brown; Susan Buchbinder; Carlos Caceres; Pedro E Cahn; Patrizia Carrieri; Georgina Caswell; Graham S Cooke; Antonella d'Arminio Monforte; Nikos Dedes; Julia Del Amo; Richard Elliott; Wafaa M El-Sadr; María José Fuster-Ruiz de Apodaca; Giovanni Guaraldi; Tim Hallett; Richard Harding; Margaret Hellard; Shabbar Jaffar; Meaghan Kall; Marina Klein; Sharon R Lewin; Ken Mayer; Jose A Pérez-Molina; Doreen Moraa; Denise Naniche; Denis Nash; Teymur Noori; Anton Pozniak; Reena Rajasuriar; Peter Reiss; Nesrine Rizk; Jürgen Rockstroh; Diana Romero; Caroline Sabin; David Serwadda; Laura Waters Journal: Nat Commun Date: 2021-07-16 Impact factor: 14.919