| Literature DB >> 31446330 |
Rim Malek1, Maciej Maj2, Artur Wnorowski2, Krzysztof Jóźwiak2, Helene Martin3, Isabel Iriepa4, Ignacio Moraleda5, Fakher Chabchoub6, José Marco-Contelles7, Lhassane Ismaili8.
Abstract
In this work we describe the synthesis, Ca+2 channel blockade capacity and antioxidant power of N3,N5-bis(2-(5-methoxy-1H-indol-3-yl)ethyl)-2,6-dimethyl-4-aryl-1,4-dihydropyridine-3,5-dicarboxamides 1-9, a number of multi-target small 1,4-dihydropyridines (DHP), designed by juxtaposition of melatonin and nimodipine. As a result, we have identified antioxidant DHP 7 (Ca2+ channel blockade: 55%, and 8.78 Trolox/Equivalents), the most balanced DHP analyzed here, for potential Alzheimer's disease therapy.Entities:
Keywords: 1,4-Dihydropyridines; Alzheimer’s disease; Antioxidants; Calcium channel blockers; Hantzsch multicomponent reaction
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Year: 2019 PMID： 31446330 DOI： 10.1016/j.bioorg.2019.103205
Source DB: PubMed Journal: Bioorg Chem ISSN： 0045-2068 Impact factor: 5.275