Rebecca A Marsh1, Jordan S Orange2. 1. Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio; Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio. 2. Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, New York; NewYork-Presbyterian Morgan Stanley Children's Hospital, New York, New York.
Abstract
OBJECTIVE: To review selected published studies related to the diagnostic evaluation of antibody deficiency. DATA SOURCES: Published literature. STUDY SELECTIONS: Studies related to the diagnostic evaluation of antibody deficiency and existing recommendations were selected. RESULTS: Many primary immunodeficiency diseases include humoral deficiency. Practical tests used in the clinical evaluation of patients for possible antibody deficiency include immunoglobulin measurement, specific antibody titers, and B-cell enumeration and phenotyping. CONCLUSION: Clinically available tests can be used to readily evaluate patients for antibody deficiencies.
OBJECTIVE: To review selected published studies related to the diagnostic evaluation of antibody deficiency. DATA SOURCES: Published literature. STUDY SELECTIONS: Studies related to the diagnostic evaluation of antibody deficiency and existing recommendations were selected. RESULTS: Many primary immunodeficiency diseases include humoral deficiency. Practical tests used in the clinical evaluation of patients for possible antibody deficiency include immunoglobulin measurement, specific antibody titers, and B-cell enumeration and phenotyping. CONCLUSION: Clinically available tests can be used to readily evaluate patients for antibody deficiencies.
Authors: Kai M T Sauerwein; Christoph B Geier; Roman F Stemberger; Hüseyin Akyaman; Peter Illes; Michael B Fischer; Martha M Eibl; Jolan E Walter; Hermann M Wolf Journal: Front Immunol Date: 2022-02-14 Impact factor: 7.561