Literature DB >> 31446075

New Insights into Beta-Cell GLP-1 Receptor and cAMP Signaling.

Alejandra Tomas1, Ben Jones2, Colin Leech3.   

Abstract

Harnessing the translational potential of the GLP-1/GLP-1R system in pancreatic beta cells has led to the development of established GLP-1R-based therapies for the long-term preservation of beta cell function. In this review, we discuss recent advances in the current research on the GLP-1/GLP-1R system in beta cells, including the regulation of signaling by endocytic trafficking as well as the application of concepts such as signal bias, allosteric modulation, dual agonism, polymorphic receptor variants, spatial compartmentalization of cAMP signaling and new downstream signaling targets involved in the control of beta cell function.
Copyright © 2019 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  GLP-1 receptor; beta cell survival; cAMP signaling; incretin; insulin secretion; pancreatic beta cell

Mesh：

Substances：

Year:  2019        PMID： 31446075     DOI： 10.1016/j.jmb.2019.08.009

Source DB:  PubMed          Journal:  J Mol Biol        ISSN： 0022-2836            Impact factor:   5.469


  14 in total

Review 1.  Revisiting the Complexity of GLP-1 Action from Sites of Synthesis to Receptor Activation.

Authors:  Brent A McLean; Chi Kin Wong; Jonathan E Campbell; David J Hodson; Stefan Trapp; Daniel J Drucker
Journal:  Endocr Rev       Date:  2021-03-15       Impact factor: 19.871

2.  Pancreatic GLP-1r binding potential is reduced in insulin-resistant pigs.

Authors:  Charles-Henri Malbert; Alain Chauvin; Michael Horowitz; Karen L Jones
Journal:  BMJ Open Diabetes Res Care       Date:  2020-11

Review 3.  Interplay Between Systemic Metabolic Cues and Autonomic Output: Connecting Cardiometabolic Function and Parasympathetic Circuits.

Authors:  Liliana Espinoza; Stephanie Fedorchak; Carie R Boychuk
Journal:  Front Physiol       Date:  2021-03-11       Impact factor: 4.566

4.  GRK2 regulates GLP-1R-mediated early phase insulin secretion in vivo.

Authors:  Alba C Arcones; Rocío Vila-Bedmar; Mercedes Mirasierra; Marta Cruces-Sande; Mario Vallejo; Ben Jones; Alejandra Tomas; Federico Mayor; Cristina Murga
Journal:  BMC Biol       Date:  2021-03-03       Impact factor: 7.431

Review 5.  Mechanisms of Beta-Cell Apoptosis in Type 2 Diabetes-Prone Situations and Potential Protection by GLP-1-Based Therapies.

Authors:  Safia Costes; Gyslaine Bertrand; Magalie A Ravier
Journal:  Int J Mol Sci       Date:  2021-05-18       Impact factor: 5.923

6.  Oligo-Fucoidan Improves Diabetes-Induced Renal Fibrosis via Activation of Sirt-1, GLP-1R, and Nrf2/HO-1: An In Vitro and In Vivo Study.

Authors:  Wen-Chun Yu; Ren-Yeong Huang; Tz-Chong Chou
Journal:  Nutrients       Date:  2020-10-08       Impact factor: 5.717

Review 7.  Emerging Role of Caveolin-1 in GLP-1 Action.

Authors:  Alessandra Puddu; Davide Maggi
Journal:  Front Endocrinol (Lausanne)       Date:  2021-04-14       Impact factor: 5.555

Review 8.  The Current State of Beta-Cell-Mass PET Imaging for Diabetes Research and Therapies.

Authors:  Pierre Cheung; Olof Eriksson
Journal:  Biomedicines       Date:  2021-12-03

9.  Macroalgal protein hydrolysates from Palmaria palmata influence the 'incretin effect' in vitro via DPP-4 inhibition and upregulation of insulin, GLP-1 and GIP secretion.

Authors:  C M McLaughlin; P A Harnedy-Rothwell; R A Lafferty; S Sharkey; V Parthsarathy; P J Allsopp; E M McSorley; R J FitzGerald; F P M O'Harte
Journal:  Eur J Nutr       Date:  2021-06-03       Impact factor: 5.614

Review 10.  The Interplay of Glucagon-Like Peptide-1 Receptor Trafficking and Signalling in Pancreatic Beta Cells.

Authors:  Amaara Marzook; Alejandra Tomas; Ben Jones
Journal:  Front Endocrinol (Lausanne)       Date:  2021-05-10       Impact factor: 5.555
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