| Literature DB >> 31446004 |
Sergey G Klochkov1, Margarita E Neganova1, Vladimir N Nikolenko2, Kuo Chen2, Siva G Somasundaram3, Cecil E Kirkland3, Gjumrakch Aliev4.
Abstract
The use of nanoparticles dramatically increases the safety and efficacy of the most common anticancer drugs. The main advantages of nano-drugs and delivery systems based on nano-technology are effective targeting, delayed release, increased half-life, and less systemic toxicity. The use of nano-carriers has led to significant improvements in drug delivery to targets compared with traditional administration of these drugs. In this review, the main tendencies in nano-drug formulations as well as factors limiting their use in clinical settings are discussed. Additionally, the current status of approved nano-drugs for cancer treatment is reviewed.Entities:
Keywords: Cancer; Drug delivery; Nano-drugs; Nano-technology; Oncotarget
Mesh:
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Year: 2019 PMID: 31446004 DOI: 10.1016/j.semcancer.2019.08.028
Source DB: PubMed Journal: Semin Cancer Biol ISSN: 1044-579X Impact factor: 15.707