Literature DB >> 31445573

Can Combination MEK and Akt Inhibition Slay the Giant Congenital Nevus?

Brandon M Murphy1, Christin E Burd2.   

Abstract

The clinical management of large and giant congenital melanocytic nevi (lgCMN) relies heavily upon iterative surgical procedures. In this issue Rouille et al. (2019) use lgCMN explants and a newly developed patient-derived xenograft model to show that the local administration of MEK and Akt inhibitors limits the lgCMN proliferative potential. These findings, along with emerging reports, support continued investigation of targeted therapies in lgCMN.
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

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Year:  2019        PMID： 31445573      PMCID： PMC6921933          DOI： 10.1016/j.jid.2019.04.009

Source DB:  PubMed          Journal:  J Invest Dermatol        ISSN： 0022-202X            Impact factor:   8.551


  11 in total

1.  Genetic Abnormalities in Large to Giant Congenital Nevi: Beyond NRAS Mutations.

Authors:  Vanessa Martins da Silva; Estefania Martinez-Barrios; Gemma Tell-Martí; Marc Dabad; Cristina Carrera; Paula Aguilera; Daniel Brualla; Anna Esteve-Codina; Asunción Vicente; Susana Puig; Joan Anton Puig-Butillé; Josep Malvehy
Journal:  J Invest Dermatol       Date:  2018-10-22       Impact factor: 8.551

2.  New recommendations for the categorization of cutaneous features of congenital melanocytic nevi.

Authors:  Sven Krengel; Alon Scope; Stephen W Dusza; Reinhard Vonthein; Ashfaq A Marghoob
Journal:  J Am Acad Dermatol       Date:  2012-09-13       Impact factor: 11.527

3.  Giant Congenital Melanocytic Nevus Treated With Trametinib.

Authors:  Adnan Mir; Nnenna G Agim; Alex A Kane; Shellie C Josephs; Jason Y Park; Kathleen Ludwig
Journal:  Pediatrics       Date:  2019-03       Impact factor: 7.124

Review 4.  Treatment of large and giant nevi.

Authors:  Bruce S Bauer; Julia Corcoran
Journal:  Clin Plast Surg       Date:  2005-01       Impact factor: 2.017

5.  Local Inhibition of MEK/Akt Prevents Cellular Growth in Human Congenital Melanocytic Nevi.

Authors:  Thomas Rouillé; Selim Aractingi; Natacha Kadlub; Sylvie Fraitag; Alexandre How-Kit; Antoine Daunay; Mikael Hivelin; Philippe Moguelet; Arnaud Picard; Romain H Fontaine; Sarah Guégan
Journal:  J Invest Dermatol       Date:  2019-05-03       Impact factor: 8.551

6.  BRAFV600E mutation status of involuting and stable nevi in dabrafenib therapy with or without trametinib.

Authors:  Phil McClenahan; Lynlee L Lin; Jean-Marie Tan; Ross Flewell-Smith; Helmut Schaider; Kasturee Jagirdar; Victoria Atkinson; Duncan Lambie; Tarl W Prow; Richard A Sturm; H Peter Soyer
Journal:  JAMA Dermatol       Date:  2014-10       Impact factor: 10.282

7.  Acute Inhibition of MEK Suppresses Congenital Melanocytic Nevus Syndrome in a Murine Model Driven by Activated NRAS and Wnt Signaling.

Authors:  Jeffrey S Pawlikowski; Claire Brock; Sheau-Chiann Chen; Lara Al-Olabi; Colin Nixon; Fiona McGregor; Simon Paine; Estelle Chanudet; Wendy Lambie; William M Holmes; James M Mullin; Ann Richmond; Hong Wu; Karen Blyth; Ayala King; Veronica A Kinsler; Peter D Adams
Journal:  J Invest Dermatol       Date:  2015-03-27       Impact factor: 8.551

Review 8.  Melanoma in congenital melanocytic naevi.

Authors:  V A Kinsler; P O'Hare; N Bulstrode; J E Calonje; W K Chong; D Hargrave; T Jacques; D Lomas; N J Sebire; O Slater
Journal:  Br J Dermatol       Date:  2017-04-04       Impact factor: 9.302

9.  MEK inhibition appears to improve symptom control in primary NRAS-driven CNS melanoma in children.

Authors:  Veronica A Kinsler; Patricia O'Hare; Thomas Jacques; Darren Hargrave; Olga Slater
Journal:  Br J Cancer       Date:  2017-03-02       Impact factor: 7.640

10.  Primary melanoma of the CNS in children is driven by congenital expression of oncogenic NRAS in melanocytes.

Authors:  Malin Pedersen; Heidi V N Küsters-Vandevelde; Amaya Viros; Patricia J T A Groenen; Berta Sanchez-Laorden; Jacobus H Gilhuis; Ilse A van Engen-van Grunsven; Willy Renier; Jolanda Schieving; Ion Niculescu-Duvaz; Caroline J Springer; Benno Küsters; Pieter Wesseling; Willeke A M Blokx; Richard Marais
Journal:  Cancer Discov       Date:  2013-01-09       Impact factor: 39.397
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  4 in total

1.  Novel insights into the pathogenesis and treatment of NRAS mutant melanoma.

Authors:  Jeffrey Zhao; Carlos Galvez; Kathryn Eby Beckermann; Douglas B Johnson; Jeffrey A Sosman
Journal:  Expert Rev Precis Med Drug Dev       Date:  2021-08-11

2.  Giant congenital melanocytic nevus of the scalp: from clinical-histological to molecular diagnosis.

Authors:  Yi Sun; Yun Zou; Lizhen Wang; Hao Gu; Qingqing Cen; Hui Chen; Xiaoxi Lin; Ren Cai
Journal:  Hereditas       Date:  2020-05-19       Impact factor: 3.271

3.  Cultured epithelial autografts for the treatment of large-to-giant congenital melanocytic nevus in 31 patients.

Authors:  Naoki Morimoto; Toshihito Mitsui; Yasuhiro Katayama; Natsuko Kakudo; Shuichi Ogino; Itaru Tsuge; Michiharu Sakamoto; Masakatsu Hihara; Kenji Kusumoto
Journal:  Regen Ther       Date:  2021-07-15       Impact factor: 3.419

4.  Novel genetic alteration in congenital melanocytic nevus: MAP2K1 germline mutation with BRAF somatic mutation.

Authors:  Yun Zou; Yi Sun; Xiaojing Zeng; Yun Liu; Qingqing Cen; Hao Gu; Xiaoxi Lin; Ren Cai; Hui Chen
Journal:  Hereditas       Date:  2020-08-26       Impact factor: 3.271
  4 in total

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