| Literature DB >> 31444468 |
Jiachang Wang1,2, Xi Liu1, An Zhang3, Yulong Ren2, Fuqing Wu2, Gang Wang3, Yang Xu1, Cailin Lei2, Shanshan Zhu2, Tian Pan1, Yongfei Wang1, Huan Zhang1, Fan Wang1, Yan-Qiu Tan3, Yupeng Wang2, Xin Jin2, Sheng Luo2, Chunlei Zhou1, Xiao Zhang1, Jinling Liu2, Shuai Wang2, Lingzhi Meng2, Yihua Wang1, Xi Chen3, Qibing Lin2, Xin Zhang2, Xiuping Guo2, Zhijun Cheng2, Jiulin Wang2, Yunlu Tian1, Shijia Liu1, Ling Jiang1, Chuanyin Wu2, Ertao Wang3, Jian-Min Zhou4, Yong-Fei Wang3, Haiyang Wang2, Jianmin Wan5.
Abstract
The transient elevation of cytoplasmic calcium is essential for pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI). However, the calcium channels responsible for this process have remained unknown. Here, we show that rice CDS1 (CELL DEATH and SUSCEPTIBLE to BLAST 1) encoding OsCNGC9, a cyclic nucleotide-gated channel protein, positively regulates the resistance to rice blast disease. We show that OsCNGC9 mediates PAMP-induced Ca2+ influx and that this event is critical for PAMPs-triggered ROS burst and induction of PTI-related defense gene expression. We further show that a PTI-related receptor-like cytoplasmic kinase OsRLCK185 physically interacts with and phosphorylates OsCNGC9 to activate its channel activity. Our results suggest a signaling cascade linking pattern recognition to calcium channel activation, which is required for initiation of PTI and disease resistance in rice.Entities:
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Year: 2019 PMID： 31444468 PMCID： PMC6796908 DOI： 10.1038/s41422-019-0219-7
Source DB: PubMed Journal: Cell Res ISSN： 1001-0602 Impact factor: 25.617