Literature DB >> 31444307

Sweet rescue or surrender of the failing heart?

Ishita Chandel1, Kelly G Ten Hagen2, Vlad Panin3.   

Abstract

Natriuretic peptides (NPs) are hormones involved in maintaining heart health that undergo proteolytic cleavage to become activated. Previous work has shown that O-GalNAc glycans affect their processing and activation. Here, Goetze, Schjoldager, and colleagues now provide comprehensive characterization of O-glycosylation of NPs, revealing that all members of the NP family can be modified by O-GalNAc glycans. Intriguingly, the study discovers glycans in the receptor-binding region of the A-type natriuretic peptide (ANP), demonstrating that they affect both stability and activity of ANP. These results may inform future therapeutic approaches for heart failure using peptide glycoforms.

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Year:  2019        PMID： 31444307      PMCID： PMC6709617          DOI： 10.1074/jbc.H119.010228

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  9 in total

1.  The precursor to B-type natriuretic peptide is an O-linked glycoprotein.

Authors:  Ute Schellenberger; Jessica O'Rear; Andrew Guzzetta; Rodney A Jue; Andrew A Protter; N Stephen Pollitt
Journal:  Arch Biochem Biophys       Date:  2006-04-19       Impact factor: 4.013

Review 2.  Atrial and brain natriuretic peptides: Hormones secreted from the heart.

Authors:  Yasuaki Nakagawa; Toshio Nishikimi; Koichiro Kuwahara
Journal:  Peptides       Date:  2018-05-31       Impact factor: 3.750

3.  The lost decade of nesiritide.

Authors:  Eric J Topol
Journal:  N Engl J Med       Date:  2011-07-07       Impact factor: 91.245

4.  Discovery of O-glycans on atrial natriuretic peptide (ANP) that affect both its proteolytic degradation and potency at its cognate receptor.

Authors:  Lasse H Hansen; Thomas Daugbjerg Madsen; Christoffer K Goth; Henrik Clausen; Yang Chen; Nina Dzhoyashvili; Seethalakshmi R Iyer; S Jeson Sangaralingham; John C Burnett; Jens F Rehfeld; Sergey Y Vakhrushev; Katrine T Schjoldager; Jens P Goetze
Journal:  J Biol Chem       Date:  2019-06-11       Impact factor: 5.157

Review 5.  Fine-Tuning Limited Proteolysis: A Major Role for Regulated Site-Specific O-Glycosylation.

Authors:  Christoffer K Goth; Sergey Y Vakhrushev; Hiren J Joshi; Henrik Clausen; Katrine T Schjoldager
Journal:  Trends Biochem Sci       Date:  2018-03-02       Impact factor: 13.807

Review 6.  Natriuretic peptide metabolism, clearance and degradation.

Authors:  Lincoln R Potter
Journal:  FEBS J       Date:  2011-04-07       Impact factor: 5.542

7.  Processing of pro-brain natriuretic peptide is suppressed by O-glycosylation in the region close to the cleavage site.

Authors:  Alexander G Semenov; Alexander B Postnikov; Natalia N Tamm; Karina R Seferian; Natalia S Karpova; Marina N Bloshchitsyna; Ekaterina V Koshkina; Mihail I Krasnoselsky; Daria V Serebryanaya; Alexey G Katrukha
Journal:  Clin Chem       Date:  2009-01-23       Impact factor: 8.327

Review 8.  Biological roles of glycans.

Authors:  Ajit Varki
Journal:  Glycobiology       Date:  2016-08-24       Impact factor: 4.313

9.  MiR30-GALNT1/2 Axis-Mediated Glycosylation Contributes to the Increased Secretion of Inactive Human Prohormone for Brain Natriuretic Peptide (proBNP) From Failing Hearts.

Authors:  Yasuaki Nakagawa; Toshio Nishikimi; Koichiro Kuwahara; Aoi Fujishima; Shogo Oka; Takayoshi Tsutamoto; Hideyuki Kinoshita; Kazuhiro Nakao; Kosai Cho; Hideaki Inazumi; Hiroyuki Okamoto; Motohiro Nishida; Takao Kato; Hiroyuki Fukushima; Jun K Yamashita; Wino J Wijnen; Esther E Creemers; Kenji Kangawa; Naoto Minamino; Kazuwa Nakao; Takeshi Kimura
Journal:  J Am Heart Assoc       Date:  2017-02-10       Impact factor: 5.501
  9 in total

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