Ga-Eun Lee1, Eric Mauro2,3, Vincent Parissi2,3, Cha-Gyun Shin1, Paul Lesbats4,5. 1. Department of Systems Biotechnology, Chung-Ang University, Anseong 17546, Korea. 2. Fundamental Microbiology and Pathogenicity Laboratory, UMR 5234 CNRS-University of Bordeaux, 33076 Bordeaux, France. 3. Viral DNA Integration and Chromatin Dynamics Network (DyNAVir), 33076 Bordeaux, France. 4. Fundamental Microbiology and Pathogenicity Laboratory, UMR 5234 CNRS-University of Bordeaux, 33076 Bordeaux, France. Paul.lesbats@u-bordeaux.fr. 5. Viral DNA Integration and Chromatin Dynamics Network (DyNAVir), 33076 Bordeaux, France. Paul.lesbats@u-bordeaux.fr.
Abstract
Foamy viruses (FV) are retroviruses belonging to the Spumaretrovirinae subfamily. They are non-pathogenic viruses endemic in several mammalian hosts like non-human primates, felines, bovines, and equines. Retroviral DNA integration is a mandatory step and constitutes a prime target for antiretroviral therapy. This activity, conserved among retroviruses and long terminal repeat (LTR) retrotransposons, involves a viral nucleoprotein complex called intasome. In the last decade, a plethora of structural insights on retroviral DNA integration arose from the study of FV. Here, we review the biochemistry and the structural features of the FV integration apparatus and will also discuss the mechanism of action of strand transfer inhibitors.
Foamy viruses (FV) are retroviruses belonging to the Spumaretrovirinae subfamily. They are non-pathogenic viruses endemic in seven class="Chemical">ralmammalian hosts like non-human primates, felines, bovines, and equines. Retroviral DNA integration is a mandatory step and constitutes a prime target for antiretroviral therapy. This activity, conserved among retroviruses and long terminal repeat (LTR) retrotransposons, involves a viral nucleoprotein complex called intasome. In the last decade, a plethora of structural insights on retroviral DNA integration arose from the study of FV. Here, we review the biochemistry and the structural features of the FV integration apparatus and will also discuss the mechanism of action of strand transfer inhibitors.