Literature DB >> 3144299

Comparative study of the bronchodilating effects of (-)- and (+)-oxyphenonium bromide.

K G Feitsma1, D S Postma, G H Koëter, G D Nossent, B F Brenth, R A de Zeeuw.   

Abstract

1. Racemic oxyphenonium bromide, its enantiomers and placebo were inhaled by eight adult patients with chronic airflow obstruction, in a four-way double-blind cross-over study. 2. Forced expiratory volume in one second (FEV1) and slow inspiratory vital capacity (VC) were measured during the first 6 h after inhalation. 3. (+)-Oxyphenonium was found to be the active enantiomer (eutomer), providing better bronchodilation than (+/-)-oxyphenonium. 4. The distomer, (-)-oxyphenonium, showed only a slight effect on FEV1 and VC as compared with placebo.

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Year:  1988        PMID： 3144299      PMCID： PMC1386444          DOI： 10.1111/j.1365-2125.1988.tb05253.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  7 in total

1.  Properties of aerosols produced with three nebulizers.

Authors:  G A Ferron; K F Kerrebijn; J Weber
Journal:  Am Rev Respir Dis       Date:  1976-11

2.  The significance of differences in the potency of enantiomers of anti-acetylcholine drugs.

Authors:  R W Brimblecombe; D M Green; T D Inch; P B Thompson
Journal:  J Pharm Pharmacol       Date:  1971-10       Impact factor: 3.765

3.  Comparison of inhaled atropine sulphate and atropine methonitrate.

Authors:  C J Allen; A H Campbell
Journal:  Thorax       Date:  1980-12       Impact factor: 9.139

4.  Studies on the stereospecificity of closely related compounds which block postganglionic acetylcholine receptors in the guinea-pig ileum.

Authors:  R B Barlow; F M Franks; J D Pearson
Journal:  J Med Chem       Date:  1973-05       Impact factor: 7.446

Review 5.  Anticholinergic, antimuscarinic bronchodilators.

Authors:  N J Gross; M S Skorodin
Journal:  Am Rev Respir Dis       Date:  1984-05

6.  Parasympatholytic (anticholinergic) esters of the isomeric 2-tropanols. 1. Glycolates.

Authors:  E R Atkinson; D D McRitchie; L F Shoer; L S Harris; S Archer; M D Aceto; J Pearl; F P Luduena
Journal:  J Med Chem       Date:  1977-12       Impact factor: 7.446

7.  Bronchodilator action of the anticholinergic drug, ipratropium bromide (Sch 1000), as an aerosol in chronic bronchitis and asthma.

Authors:  W Baigelman; S Chodosh
Journal:  Chest       Date:  1977-03       Impact factor: 9.410
  7 in total
  1 in total

1.  CuH-Catalyzed Enantioselective Ketone Allylation with 1,3-Dienes: Scope, Mechanism, and Applications.

Authors:  Chengxi Li; Richard Y Liu; Luke T Jesikiewicz; Yang Yang; Peng Liu; Stephen L Buchwald
Journal:  J Am Chem Soc       Date:  2019-03-12       Impact factor: 15.419
  1 in total

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