Mohammed Abdelkareem1, Yahya Wahba2, Basma Shouman1, Abeer Mesbah3. 1. Department of Pediatrics, Faculty of Medicine, Mansoura University, Mansoura, Egypt. 2. Department of Pediatrics, Faculty of Medicine, Mansoura University, Mansoura, Egypt. Correspondence to: Dr Yahya Wahba, Assistant Professor, Department of Pediatrics, Faculty of Medicine, Mansoura University, 35516, Mansoura, Egypt. wahbayahya2007@mans.edu.eg. 3. Departments of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Abstract
OBJECTIVE: To compare the effects of two different intravenous lipid emulsions on soluble adhesion markers in preterm infants with sepsis. METHODS: This randomized controlled pilot trial was conducted from February 2016 to February 2017. 40 preterm infants with sepsis were enrolled and assigned to receive either Medium chain triglyceride-Olive-Fish-Soy lipid emulsion (MOFS-LE) or soybean oil-based lipid emulsion (S-LE). Outcomes of the study were changes in sICAM-1 and leukocyte integrin b2 levels, and growth after 7 days of intervention. RESULTS:Leukocyte integrin b2 was significantly higher in MOFS-LE group. No statistically significant differences were observed for sICAM-1, duration of mechanical ventilation and antibiotics treatment, and mortality rate. CONCLUSIONS:Leukocyte integrin b2 was significantly higher in preterm septic neonates who received MOFS-LE.
RCT Entities:
OBJECTIVE: To compare the effects of two different intravenous lipid emulsions on soluble adhesion markers in preterm infants with sepsis. METHODS: This randomized controlled pilot trial was conducted from February 2016 to February 2017. 40 preterm infants with sepsis were enrolled and assigned to receive either Medium chain triglyceride-Olive-Fish-Soy lipid emulsion (MOFS-LE) or soybean oil-based lipid emulsion (S-LE). Outcomes of the study were changes in sICAM-1 and leukocyte integrin b2 levels, and growth after 7 days of intervention. RESULTS: Leukocyte integrin b2 was significantly higher in MOFS-LE group. No statistically significant differences were observed for sICAM-1, duration of mechanical ventilation and antibiotics treatment, and mortality rate. CONCLUSIONS: Leukocyte integrin b2 was significantly higher in preterm septic neonates who received MOFS-LE.