Robyn Larsen1, Hamza Ali1, Paddy C Dempsey1,2,3, Megan Grace1, Francis Dillon1, Bronwyn A Kingwell1,4,5, Neale Cohen1,6, Neville Owen1,3,7,8, Daniel J Green9, David W Dunstan1,9,10,11,12. 1. Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia. 2. Institute of Metabolic Science, University of Cambridge, England, UK. 3. Centre for Urban Transitions, Swinburne University of Technology, Melbourne, Victoria, Australia. 4. Faculty of Medicine, Monash University, Melbourne, Victoria, Australia. 5. Department of Physiology, Monash University, Melbourne, Victoria, Australia. 6. School of Pharmacy, University of Queensland, St. Lucia, Brisbane, Queensland, Australia. 7. School of Population Health, University of Queensland, Brisbane, Queensland, Australia. 8. Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia. 9. School of Human Sciences (Exercise and Sport Science), University of Western Australia, Perth, Western Australia, Australia. 10. School of Exercise and Nutrition Sciences, Deakin University, Melbourne, Victoria, Australia. 11. Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia. 12. Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Victoria, Australia.
Abstract
OBJECTIVE: This study aimed to examine the effects on postprandial glucose and insulin responses of interrupting sitting time with brief bouts of simple resistance activities (SRAs) in adults with overweight or obesity. METHODS:Participants (n = 19) were recruited for a randomized crossover trial involving the following two 6-hour conditions: (1) uninterrupted sitting or (2) sitting with 3-minute bouts of SRAs (half-squats, calf raises, gluteal contractions, and knee raises) every 30 minutes (total duration = 27 minutes). Incremental areas under the curve (iAUC) for glucose, insulin, and insulin:glucose ratio were analyzed as prespecified secondary outcomes using mixed-effects log-linear regression adjusted for sex, BMI, treatment order, and preprandial values. Results are reported as multiplicative change (exponentiated coefficient [EC] with 95% CI) relative to the control condition. RESULTS:Glucose iAUC during the SRA condition was not significantly different from the prolonged sitting condition (EC = 0.92; 95% CI: 0.73-1.16; P = 0.43). However, SRAs lowered the postprandial insulin response by 26% (EC = 0.74; 95% CI: 0.64-0.85; P < 0.001), and there was a 23% lowering of the iAUC for insulin:glucose (EC = 0.77; 95% CI: 0.67-0.89; P < 0.001). CONCLUSIONS: In adults with overweight or obesity, frequent interruptions to sitting time with SRAs lowered postprandial insulin responses and insulin:glucose. These findings may have implications for mitigating cardiometabolic risk in adults with overweight or obesity who engage in prolonged periods of sitting.
RCT Entities:
OBJECTIVE: This study aimed to examine the effects on postprandial glucose and insulin responses of interrupting sitting time with brief bouts of simple resistance activities (SRAs) in adults with overweight or obesity. METHODS:Participants (n = 19) were recruited for a randomized crossover trial involving the following two 6-hour conditions: (1) uninterrupted sitting or (2) sitting with 3-minute bouts of SRAs (half-squats, calf raises, gluteal contractions, and knee raises) every 30 minutes (total duration = 27 minutes). Incremental areas under the curve (iAUC) for glucose, insulin, and insulin:glucose ratio were analyzed as prespecified secondary outcomes using mixed-effects log-linear regression adjusted for sex, BMI, treatment order, and preprandial values. Results are reported as multiplicative change (exponentiated coefficient [EC] with 95% CI) relative to the control condition. RESULTS:Glucose iAUC during the SRA condition was not significantly different from the prolonged sitting condition (EC = 0.92; 95% CI: 0.73-1.16; P = 0.43). However, SRAs lowered the postprandial insulin response by 26% (EC = 0.74; 95% CI: 0.64-0.85; P < 0.001), and there was a 23% lowering of the iAUC for insulin:glucose (EC = 0.77; 95% CI: 0.67-0.89; P < 0.001). CONCLUSIONS: In adults with overweight or obesity, frequent interruptions to sitting time with SRAs lowered postprandial insulin responses and insulin:glucose. These findings may have implications for mitigating cardiometabolic risk in adults with overweight or obesity who engage in prolonged periods of sitting.
Authors: Ashleigh R Homer; Frances C Taylor; Paddy C Dempsey; Michael J Wheeler; Parneet Sethi; Melanie K Townsend; Megan S Grace; Daniel J Green; Neale D Cohen; Robyn N Larsen; Bronwyn A Kingwell; Neville Owen; David W Dunstan Journal: Diabetes Care Date: 2021-04-26 Impact factor: 17.152
Authors: Roman P Kuster; Wilhelmus J A Grooten; Victoria Blom; Daniel Baumgartner; Maria Hagströmer; Örjan Ekblom Journal: Int J Environ Res Public Health Date: 2020-11-28 Impact factor: 3.390