Ikuma Wakamatsu1, Haruhisa Matsuguma2, Rie Nakahara2, Masayuki Chida3. 1. Division of Thoracic Surgery, Tochigi Cancer Center, 4-9-13 Yohnan, Utsunomiya, 320-0834, Tochigi, Japan. ikumwaka@tochigi-cc.jp. 2. Division of Thoracic Surgery, Tochigi Cancer Center, 4-9-13 Yohnan, Utsunomiya, 320-0834, Tochigi, Japan. 3. Department of General Thoracic Surgery, Dokkyo Medical University, Mibu, Tochigi, Japan.
Abstract
PURPOSE: To establish the factors associated with compensatory lung growth (CLG) in human adults. METHODS: The subjects of this study were 216 patients who underwent pulmonary lobectomy between January 2008 and March 2015 and had computed tomography (CT) scans done before and 2 years after surgery with no signs of recurrence. The predicted postoperative values of lung volume and lung weight, based on the preoperative CT data, were compared with those 2 years after surgery. RESULTS: When the predicted postoperative values were considered to be 100%, the mean lung volume and lung weight 2 years after surgery were 116 ± 16% and 115 ± 19%, respectively. CLG was defined as both lung volume ≥ 110% and lung weight ≥ 106% (CLG group; n = 108). Both univariate and multivariate analyses showed that younger age (≤ 60 years), a larger number of resected subsegments (≥ 10), and a light- (< 20 pack-years) or non-smoking history were significantly associated with CLG. CONCLUSIONS: This study identified younger age, a light- or non-smoking history, and a large resection volume as the predictors of CLG in patients who underwent pulmonary lobectomy for lung malignancy. All of these three factors may be reasonably connected to CLG.
PURPOSE: To establish the factors associated with compensatory lung growth (CLG) in human adults. METHODS: The subjects of this study were 216 patients who underwent pulmonary lobectomy between January 2008 and March 2015 and had computed tomography (CT) scans done before and 2 years after surgery with no signs of recurrence. The predicted postoperative values of lung volume and lung weight, based on the preoperative CT data, were compared with those 2 years after surgery. RESULTS: When the predicted postoperative values were considered to be 100%, the mean lung volume and lung weight 2 years after surgery were 116 ± 16% and 115 ± 19%, respectively. CLG was defined as both lung volume ≥ 110% and lung weight ≥ 106% (CLG group; n = 108). Both univariate and multivariate analyses showed that younger age (≤ 60 years), a larger number of resected subsegments (≥ 10), and a light- (< 20 pack-years) or non-smoking history were significantly associated with CLG. CONCLUSIONS: This study identified younger age, a light- or non-smoking history, and a large resection volume as the predictors of CLG in patients who underwent pulmonary lobectomy for lung malignancy. All of these three factors may be reasonably connected to CLG.
Authors: James P Butler; Stephen H Loring; Samuel Patz; Akira Tsuda; Dmitriy A Yablonskiy; Steven J Mentzer Journal: N Engl J Med Date: 2012-07-19 Impact factor: 91.245
Authors: A Yoshitomi; H Kuwata; T Suzuki; M Masuda; M Narushima; T Nakajima; S Imokawa; T Suda; K Chida; H Nakamura Journal: Nihon Kokyuki Gakkai Zasshi Date: 2000-08