| Literature DB >> 31440896 |
Dirk Bandorski1,2, Reinhard Höltgen3, Ardeschir Ghofrani4, Viktoria Johnson5, Jörn Schmitt5.
Abstract
Pulmonary arterial hypertension (PAH) occurs in 1% of the global population and can be divided in different disease groups. Pathophysiological aspects leading to supraventricular arrhythmias in these patients are due to increased pulmonary and right atrial pressure, increased activity of the sympathetic nervous system leading to right atrial electrical remodeling and ischemia in the right atrium. In the clinical setting these patients present with atrial flutter, atrial fibrillation or with ectopic atrial tachycardia. Regarding ventricular tachycardia there is a lack of data. Occurrence of arrhythmia in these patients leads to a deterioration of PAH, so rhythm control should be the aim. This can be achieved by right atrial ablation, especially in patients presenting with atrial flutter; electric cardioversion or antiarrhythmic drug therapy are without definite guideline recommendations since there are too few clinical trials. Ablation with a transseptal approach in the left atrium is considered rather dangerous and should be avoided. Regarding arrhythmias in patients with chronic lung disease, few data are available. For patients with chronic obstructive pulmonary disease (COPD), there are good data available. These patients often suffer from coronary heart disease, atrial fibrillation, and ventricular tachycardia. Beta-blockers play an important role in COPD patients, even during exacerbation. Interventional therapies are safe but the arrhythmogenic foci often located outside of the pulmonary veins (in the right atrium).Entities:
Keywords: Arrhythmia; Bradycardia; Chronic obstructive lung disease; Pulmonary hypertension; Tachycardia
Mesh:
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Year: 2019 PMID: 31440896 DOI: 10.1007/s00399-019-00637-y
Source DB: PubMed Journal: Herzschrittmacherther Elektrophysiol ISSN: 0938-7412