OBJECTIVE: To examine the effects of individualized regular coaching and exercise on post-stroke cognitive and emotional function. METHODS: The Life After STroke (LAST) study investigated the differences between intervention and care-as-usual between 3 and 21 months post-stroke. Outcome measures were the Trail Making Test (TMT) A and B, Mini Mental State Examination (MMSE), Hospital Anxiety and Depression Scale (HADS), and adherence to the intervention. RESULTS: Of the 362 patients included in the study, 177 were assigned to the intervention. The mean age was 71.7 (SD 11.3) years and 39.5% were female. The adjusted mean difference between groups for TMT A was 8.54 (CI 0.7 to 16.3), p = 0.032, for TMT B 8.6 (CI -16.5 to 33.6), p = 0.50, for MMSE -0.1 (CI -0.8 to 0. 6), p = 0.77, for HADS A -0.2 (CI -0.9 to 0.5), p = 0.56 and for HADS D -0.1 (CI -0.7 to 0.5), p = 0.76). A higher level of adherence to the intervention was significantly associated with increased MMSE (B = 0.030 (CI 0.005-0.055), p = 0.020) Conclusion: No clinically relevant effects on cognitive or emotional function were found of individualized regular coaching for physical activity and exercise. However, increased adherence to the intervention was associated with improved cognitive function.
RCT Entities:
OBJECTIVE: To examine the effects of individualized regular coaching and exercise on post-stroke cognitive and emotional function. METHODS: The Life After STroke (LAST) study investigated the differences between intervention and care-as-usual between 3 and 21 months post-stroke. Outcome measures were the Trail Making Test (TMT) A and B, Mini Mental State Examination (MMSE), Hospital Anxiety and Depression Scale (HADS), and adherence to the intervention. RESULTS: Of the 362 patients included in the study, 177 were assigned to the intervention. The mean age was 71.7 (SD 11.3) years and 39.5% were female. The adjusted mean difference between groups for TMT A was 8.54 (CI 0.7 to 16.3), p = 0.032, for TMT B 8.6 (CI -16.5 to 33.6), p = 0.50, for MMSE -0.1 (CI -0.8 to 0. 6), p = 0.77, for HADS A -0.2 (CI -0.9 to 0.5), p = 0.56 and for HADS D -0.1 (CI -0.7 to 0.5), p = 0.76). A higher level of adherence to the intervention was significantly associated with increased MMSE (B = 0.030 (CI 0.005-0.055), p = 0.020) Conclusion: No clinically relevant effects on cognitive or emotional function were found of individualized regular coaching for physical activity and exercise. However, increased adherence to the intervention was associated with improved cognitive function.
Authors: Terence J Quinn; Edo Richard; Yvonne Teuschl; Thomas Gattringer; Melanie Hafdi; John T O'Brien; Niamh Merriman; Celine Gillebert; Hanne Huyglier; Ana Verdelho; Reinhold Schmidt; Emma Ghaziani; Hysse Forchammer; Sarah T Pendlebury; Rose Bruffaerts; Milija Mijajlovic; Bogna A Drozdowska; Emily Ball; Hugh S Markus Journal: Eur Stroke J Date: 2021-10-08
Authors: Qing Zhao; Xue Wang; Tao Wang; Adam A Dmytriw; Xiao Zhang; Kun Yang; Jichang Luo; Xuesong Bai; Nan Jiang; Bin Yang; Yan Ma; Liqun Jiao; Yunyan Xie Journal: Syst Rev Date: 2021-03-04
Authors: David H Saunders; Gillian E Mead; Claire Fitzsimons; Paul Kelly; Frederike van Wijck; Olaf Verschuren; Karianne Backx; Coralie English Journal: Cochrane Database Syst Rev Date: 2021-06-29