Literature DB >> 3143953

Implantable microencapsulated dopamine (DA): a new approach for slow-release DA delivery into brain tissue.

A McRae-Degueurce1, S Hjorth, D L Dillon, D W Mason, T R Tice.   

Abstract

Biodegradable controlled-release systems constitute an exciting new technology for drug delivery to the central nervous system (CNS). The present study describes functional and histochemical observations, indicating that implantation of DA microcapsules into striatal tissue assures a prolonged release of the transmitter in situ. This technology has considerable potential for basic and possibly also clinical research.

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Year:  1988        PMID: 3143953     DOI: 10.1016/0304-3940(88)90607-6

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN: 0304-3940            Impact factor:   3.046


  3 in total

Review 1.  Determinants of passive drug entry into the central nervous system.

Authors:  M D Habgood; D J Begley; N J Abbott
Journal:  Cell Mol Neurobiol       Date:  2000-04       Impact factor: 5.046

Review 2.  Distribution of drugs following controlled delivery to the brain interstitium.

Authors:  M Mak; L Fung; J F Strasser; W M Saltzman
Journal:  J Neurooncol       Date:  1995-11       Impact factor: 4.130

3.  Catecholamine-containing biodegradable microsphere implants as a novel approach in the treatment of CNS neurodegenerative disease. A review of experimental studies in DA-lesioned rats.

Authors:  A McRae; E A Ling; S Hjorth; A Dahlström; D Mason; T Tice
Journal:  Mol Neurobiol       Date:  1994 Aug-Dec       Impact factor: 5.590

  3 in total

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