Yixue Shao1, Hui Shao1, Monika S Sawhney2, Lizheng Shi3. 1. Department of Health Policy and Management, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA. 2. Department of Public Health Sciences, The University of North Carolina at Charlotte College of Health and Human Services, Charlotte, NC, USA. 3. Department of Health Policy and Management, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA. Electronic address: lshi1@tulane.edu.
Abstract
AIMS: To explore the association between serum uric acid (SUA) level and the risk of cardiovascular complications and all-cause mortality rates among individuals with type 2 diabetes. METHODS: Web of Science and PubMed database were searched for studies reported associations between SUA level and cardiovascular complications and all-cause mortality among individuals with type 2 diabetes. Hazard ratios (HRs) were independently extracted by two investigators and synthesized through meta-analysis across selected studies. RESULTS: 6 (n = 11,750 patients), 4 (n = 3044 patients) and 2 studies (n = 7792 patients) were identified reporting associations between SUA level and all-cause mortality, coronary heart disease (CHD) and stroke respectively. HR for all-cause mortality, CHD, and stroke per 59 μmol/l increase was 1.06 (95% CI: 1.03, 1.09), 1.09 (95% CI: 0.94, 1.26) and 1.19 (95% CI: 1.08, 1.31), respectively. CONCLUSIONS: Overall, the SUA level was associated with a higher risk of all-cause mortality and stroke. We found no significant association between SUA level and CHD among type 2 diabetes population.
AIMS: To explore the association between serum uric acid (SUA) level and the risk of cardiovascular complications and all-cause mortality rates among individuals with type 2 diabetes. METHODS: Web of Science and PubMed database were searched for studies reported associations between SUA level and cardiovascular complications and all-cause mortality among individuals with type 2 diabetes. Hazard ratios (HRs) were independently extracted by two investigators and synthesized through meta-analysis across selected studies. RESULTS: 6 (n = 11,750 patients), 4 (n = 3044 patients) and 2 studies (n = 7792 patients) were identified reporting associations between SUA level and all-cause mortality, coronary heart disease (CHD) and stroke respectively. HR for all-cause mortality, CHD, and stroke per 59 μmol/l increase was 1.06 (95% CI: 1.03, 1.09), 1.09 (95% CI: 0.94, 1.26) and 1.19 (95% CI: 1.08, 1.31), respectively. CONCLUSIONS: Overall, the SUA level was associated with a higher risk of all-cause mortality and stroke. We found no significant association between SUA level and CHD among type 2 diabetes population.
Authors: Subodh Verma; Qiuhe Ji; Deepak L Bhatt; C David Mazer; Mohammed Al-Omran; Silvio E Inzucchi; Christoph Wanner; Anne Pernille Ofstad; Isabella Zwiener; Jyothis T George; Bernard Zinman; David Fitchett Journal: Diabetes Obes Metab Date: 2020-03-28 Impact factor: 6.577