Jin Go1, KyungJai Ko2, Dami Jun3, Su-Kyung Kwon3, Sanghyeop Han4, Young Hwa Kim5, Mi-Hyeong Kim6, Kang Woong Jun7, JeongKye Hwang6, Sang Dong Kim8, Sun Cheol Park9, Ji-Il Kim10, Sang Seob Yun3, InSung Moon11. 1. Department of Surgery, Mediplex Sejong Hospital, Incheon, Republic of Korea. 2. Department of Surgery, Kangdong Sacred Heart Hospital, Seoul, Republic of Korea. 3. Department of Surgery, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea. 4. Department of Surgery, Chuncheon Sacred Heart Hospital, Hallym University, Chuncheon, Republic of Korea. 5. Department of Surgery, Daejeon St. Mary's Hospital, The Catholic University of Korea, Daejeon, Republic of Korea. 6. Department of Surgery, Eunpyeong St. Mary's Hospital, The Catholic University of Korea, Incheon, Republic of Korea. 7. Department of Surgery, Bucheon St. Mary's Hospital, The Catholic University of Korea, Gyeonggi, Republic of Korea. 8. Department of Surgery, Incheon St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea. 9. Department of Surgery, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea. Electronic address: sun60278@catholic.ac.kr. 10. Department of Surgery, Uijeongbu St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea. 11. Department of Surgery, Yeouido St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.
Abstract
BACKGROUND: This study aims to analyze the entire registry of kidney transplant over the past 50 years and understand the clinical significance. METHODS: From the data on 3012 kidney transplants performed at our center between March 1969 and September 2018, we analyzed retrospectively clinical variables. RESULTS: Until September 2018, there have been 3012 kidney transplants performed. The number of primary transplant cases was 2755 (91.8%), which included 16 cases of simultaneous liver-kidney transplant, and the number of repeated transplants was 245 (225 second transplants [7.5%] and 20 third transplants [0.7%]). There were 3 simultaneous pancreas kidney transplants, and 3 small bowel-kidney transplants, one of them being transplanted at the same time. There was a single simultaneous heart-kidney transplant. The viability rates of a transplanted kidney for 1, 5, 10, 20, and 30 years were 97%, 92%, 90%, 51%, and 36%, respectively, and the patient survival rates were 96%, 89%, 82%, 64%, and 52%, respectively. Five-year graft survival rate of the first 1000 cases was 64.6%; those of the 1001st to 2000th cases and 2001st to 3012th cases were 87.6% and 88.8%, respectively. There are statistically significant differences among the groups. CONCLUSION: This study has identified the appropriate selection or control of immunotherapy, based on the risk level of kidney transplant recipient, is needed to minimize chronic rejection, which is the key cause of transplanted kidney failure.
BACKGROUND: This study aims to analyze the entire registry of kidney transplant over the past 50 years and understand the clinical significance. METHODS: From the data on 3012 kidney transplants performed at our center between March 1969 and September 2018, we analyzed retrospectively clinical variables. RESULTS: Until September 2018, there have been 3012 kidney transplants performed. The number of primary transplant cases was 2755 (91.8%), which included 16 cases of simultaneous liver-kidney transplant, and the number of repeated transplants was 245 (225 second transplants [7.5%] and 20 third transplants [0.7%]). There were 3 simultaneous pancreas kidney transplants, and 3 small bowel-kidney transplants, one of them being transplanted at the same time. There was a single simultaneous heart-kidney transplant. The viability rates of a transplanted kidney for 1, 5, 10, 20, and 30 years were 97%, 92%, 90%, 51%, and 36%, respectively, and the patient survival rates were 96%, 89%, 82%, 64%, and 52%, respectively. Five-year graft survival rate of the first 1000 cases was 64.6%; those of the 1001st to 2000th cases and 2001st to 3012th cases were 87.6% and 88.8%, respectively. There are statistically significant differences among the groups. CONCLUSION: This study has identified the appropriate selection or control of immunotherapy, based on the risk level of kidney transplant recipient, is needed to minimize chronic rejection, which is the key cause of transplanted kidney failure.
Authors: Jong Cheol Jeong; Tai Yeon Koo; Han Ro; Dong Ryeol Lee; Dong Won Lee; Jieun Oh; Jayoun Kim; Dong-Wan Chae; Young Hoon Kim; Kyu Ha Huh; Jae Berm Park; Yeong Hoon Kim; Seungyeup Han; Soo Jin Na Choi; Sik Lee; Sang-Il Min; Jongwon Ha; Myoung Soo Kim; Curie Ahn; Jaeseok Yang Journal: Sci Rep Date: 2022-05-24 Impact factor: 4.996