OBJECTIVES: The aim of this study was to investigate the impact of improved glycemic control on atrial fibrillation (AF) recurrence rates after ablation. BACKGROUND: Diabetes is associated with increased rates of AF. The impact of improved pre-ablation glycemic control remains unknown. METHODS: The 12-month pre-ablation trends in glycemic control were studied in 298 patients with diabetes undergoing AF ablation. Recurrence data were obtained during a mean follow-up period of 25.92 ± 20.26 months post-ablation. RESULTS: Higher glycated hemoglobin (HbA1c) at the time of ablation was associated with higher post-ablation recurrence rates. More than two-thirds (68.75%) of patients with HbA1c >9% at the time of ablation developed recurrent AF, compared with 32.4% of those with HbA1c <7% (p < 0.0001). On multivariate analysis, only the 12-month trend in HbA1c was significantly associated with AF recurrence. Although 91.1% of patients with a worsening trend in HbA1c during the 12 months prior to ablation developed recurrent AF, only 2% of patients with improvements in HbA1c of 10% or more experienced AF recurrence (p < 0.0001). CONCLUSIONS: The trend in glycemic control prior to ablation predicts arrhythmia recurrence after ablation. A multidisciplinary approach to reduce HbA1c is imperative in patients with diabetes with AF to reduce recurrence rates after ablation.
OBJECTIVES: The aim of this study was to investigate the impact of improved glycemic control on atrial fibrillation (AF) recurrence rates after ablation. BACKGROUND:Diabetes is associated with increased rates of AF. The impact of improved pre-ablation glycemic control remains unknown. METHODS: The 12-month pre-ablation trends in glycemic control were studied in 298 patients with diabetes undergoing AF ablation. Recurrence data were obtained during a mean follow-up period of 25.92 ± 20.26 months post-ablation. RESULTS: Higher glycated hemoglobin (HbA1c) at the time of ablation was associated with higher post-ablation recurrence rates. More than two-thirds (68.75%) of patients with HbA1c >9% at the time of ablation developed recurrent AF, compared with 32.4% of those with HbA1c <7% (p < 0.0001). On multivariate analysis, only the 12-month trend in HbA1c was significantly associated with AF recurrence. Although 91.1% of patients with a worsening trend in HbA1c during the 12 months prior to ablation developed recurrent AF, only 2% of patients with improvements in HbA1c of 10% or more experienced AF recurrence (p < 0.0001). CONCLUSIONS: The trend in glycemic control prior to ablation predicts arrhythmia recurrence after ablation. A multidisciplinary approach to reduce HbA1c is imperative in patients with diabetes with AF to reduce recurrence rates after ablation.
Authors: Amaya García-Fernández; María Asunción Esteve-Pastor; Inmaculada Roldán-Rabadán; Javier Muñiz; Martín Ruiz Ortiz; Ángel Cequier; Vicente Bertomeu-Martínez; Lina Badimón; Déborah Otero; Manuel Anguita; Gregory Y H Lip; Francisco Marín Journal: Ann Med Date: 2020-06-17 Impact factor: 4.709
Authors: Niraj Varma; Iwona Cygankiewicz; Mintu P Turakhia; Hein Heidbuchel; Yu-Feng Hu; Lin Yee Chen; Jean-Philippe Couderc; Edmond M Cronin; Jerry D Estep; Lars Grieten; Deirdre A Lane; Reena Mehra; Alex Page; Rod Passman; Jonathan P Piccini; Ewa Piotrowicz; Ryszard Piotrowicz; Pyotr G Platonov; Antonio Luiz Ribeiro; Robert E Rich; Andrea M Russo; David Slotwiner; Jonathan S Steinberg; Emma Svennberg Journal: Circ Arrhythm Electrophysiol Date: 2021-02-12
Authors: Niraj Varma; Iwona Cygankiewicz; Mintu P Turakhia; Hein Heidbuchel; Yufeng Hu; Lin Yee Chen; Jean-Philippe Couderc; Edmond M Cronin; Jerry D Estep; Lars Grieten; Deirdre A Lane; Reena Mehra; Alex Page; Rod Passman; Jonathan P Piccini; Ewa Piotrowicz; Ryszard Piotrowicz; Pyotr G Platonov; Antonio Luiz Ribeiro; Robert E Rich; Andrea M Russo; David Slotwiner; Jonathan S Steinberg; Emma Svennberg Journal: Cardiovasc Digit Health J Date: 2021-01-29
Authors: Marjan Firouznia; Albert K Feeny; Michael A LaBarbera; Meghan McHale; Catherine Cantlay; Natalie Kalfas; Paul Schoenhagen; Walid Saliba; Patrick Tchou; John Barnard; Mina K Chung; Anant Madabhushi Journal: Circ Arrhythm Electrophysiol Date: 2021-02-12
Authors: Wendy Wang; Faye L Norby; Mary R Rooney; Michael Zhang; Alejandra Gutierrez; Parveen Garg; Elsayed Z Soliman; Alvaro Alonso; Samuel C Dudley; Pamela L Lutsey; Lin Y Chen Journal: Am J Cardiol Date: 2020-09-28 Impact factor: 2.778
Authors: David Bode; Lukas Semmler; Christian U Oeing; Alessio Alogna; Gabriele G Schiattarella; Burkert M Pieske; Frank R Heinzel; Felix Hohendanner Journal: Int J Mol Sci Date: 2021-05-31 Impact factor: 5.923
Authors: Allen Wang; Tracy Truong; Eric Black-Maier; Cynthia Green; Kristen B Campbell; Adam S Barnett; Janice Febre; Zak Loring; Sana M Al-Khatib; Brett D Atwater; James P Daubert; Camille Frazier-Mills; Donald D Hegland; Kevin P Jackson; Larry R Jackson; Jason I Koontz; Robert K Lewis; Sean D Pokorney; Albert Y Sun; Kevin L Thomas; Tristam D Bahnson; Jonathan P Piccini Journal: Heart Rhythm O2 Date: 2020-05-12