FoxOs could play an important role during influenza A viruses infection via microarray analysis based on GEO database.

Influenza is a highly contagious respiratory illness caused by influenza A viruses (IAVs). The response and reaction from the host vary due to different subtypes. In this study, we identified the global transcriptomics of HUVEC (human umbilical vein endothelial cells) and macrophage cells after infection of H5N1 and H1N1 strains using microarray data from Gene Expression Omnibus (GEO), respectively. Our data showed that influenza A viruses (IAVs) could induce more global profound transcriptomics in HUVEC than macrophage cells. H5N1 infection led to much more rigorous apoptosis than H1N1 did in macrophage cells. Our data is consistent with the idea that by maintaining normal levels of FoxO1 could be maintained, the pro-apoptotic effects of IAV virus infection could be reduced. Anti-inflammatory and anti-apoptosis responses could be manipulated via FoxOs in response to IAVs infection, indicating that FoxOs could function as candidate target for the treatment of IAVs infection. Our result thus provides new insight for the future strategy of anti-IAVs therapy.