Erfaneh Salimi1, Mojgan Karimi-Zarchi2, Seyed Alireza Dastgheib3, Hajar Abbasi1, Razieh Sadat Tabatabaiee4, Amaneh Hadadan4, Nooshin Amjadi1, Mohammad Javad Akbarian-Bafghi5, Hossein Neamatzadeh6. 1. Department of Gynecology and Obstetrics, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 2. Department of Gynecology and Obstetrics, Iran University of Medical Sciences, Tehran, Iran. 3. Department of Medical Genetics, Shiraz University of Medical Sciences, Shiraz, Iran. 4. Department of Gynecology and Obstetrics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 5. Department of Healthcare Management, Bam University of Medical Sciences, Bam, Iran. 6. Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Abstract
Background: The present meta-analysis was performed to investigate the association of promoter region polymorphisms at IL-6 and IL-18 genes with recurrent pregnancy loss (RPL) risk. Methods: An electronic search of the PubMed, Embase, ISI Web of Knowledge and CNKI databases was performed to identify eligible studies up to May 30, 2019. Results: A total of 31 case-control studies were finally selected. Significant associations with the risk of RPL were detected for the IL-6 -174 G > C, -634 G > C and IL-18 -137 G > C polymorphisms in overall population. Further, subgroup analyses by ethnicity revealed that the IL-6 -174 G > C and -634 G > C polymorphisms were significantly associated with risk of RPL risk in Asians. Conclusions: Our results suggest that the IL-6 -174 G > C, -634 G > C and IL-18 -137 G > C polymorphisms may contribute to the susceptibility of RPL. The IL-18 -607 C > A polymorphism does not appear to influence the development of RPL.
Background: The present meta-analysis was performed to investigate the association of promoter region polymorphisms at IL-6 and IL-18 genes with recurrent pregnancy loss (RPL) risk. Methods: An electronic search of the PubMed, Embase, ISI Web of Knowledge and CNKI databases was performed to identify eligible studies up to May 30, 2019. Results: A total of 31 case-control studies were finally selected. Significant associations with the risk of RPL were detected for the IL-6 -174 G > C, -634 G > C and IL-18 -137 G > C polymorphisms in overall population. Further, subgroup analyses by ethnicity revealed that the IL-6 -174 G > C and -634 G > C polymorphisms were significantly associated with risk of RPL risk in Asians. Conclusions: Our results suggest that the IL-6 -174 G > C, -634 G > C and IL-18 -137 G > C polymorphisms may contribute to the susceptibility of RPL. The IL-18 -607 C > A polymorphism does not appear to influence the development of RPL.