| Literature DB >> 31436778 |
Zhiyu Liu1, Zexin Wang, Erteng Jia, Tinglan Ouyang, Min Pan, Jiafeng Lu, Qinyu Ge, Yunfei Bai.
Abstract
DNA methylation is an important epigenetic marker that affects gene expression. Cell-free DNA methylation detection is a promising approach as abnormal distribution of DNA methylation is one of the hallmarks of many cancers and methylation changes occur early during carcinogenesis. This review summarizes the existing literature and reviews on the detection methods based on next generation sequencing for DNA methylation. The review also discusses the feasibility of detecting cfDNA methylation and the latest progress.Entities:
Mesh:
Substances:
Year: 2019 PMID: 31436778 DOI: 10.1039/c9an00935c
Source DB: PubMed Journal: Analyst ISSN: 0003-2654 Impact factor: 4.616