Jane E Gross1,2,3, Stacey L Martiniano4,3, Jerry A Nick2,3. 1. Department of Pediatrics. 2. Department of Medicine, National Jewish Health, Denver, Colorado. 3. University of Colorado Anschutz Medical Campus, School of Medicine, Aurora, Colorado, USA. 4. Children's Hospital Colorado.
Abstract
PURPOSE OF REVIEW: Pulmonary nontuberculous mycobacterial (NTM) infection is recognized as one of the most challenging infections to treat among cystic fibrosis patients. The source of NTM infection, modes of transmission, and exposure risks are poorly understood. Healthcare-associated transmission of Mycobacterium abscessus among cystic fibrosis patients has been suspected and is a growing concern for cystic fibrosis centers worldwide. This review describes our current understanding of prevention of healthcare-associated transmission of M. abscessus among patients with cystic fibrosis. RECENT FINDINGS: Multiple healthcare-associated outbreaks of M. abscessus among cystic fibrosis patients within cystic fibrosis care centers have been reported. The percentage of patients involved in the reported outbreaks, as well as the perceived impact of patient-to-patient transmission varies dramatically between the reporting centers and population surveys. Several groups have now proposed M. abscessus-specific measures to limit future outbreaks. SUMMARY: Improved NTM surveillance combined with a standardized, systematic approach to epidemiologic investigation of potential episodes of healthcare-associated transmission will help to reveal risk factors for NTM acquisition and inform future evidence-based infection prevention and control measures for patients with cystic fibrosis.
PURPOSE OF REVIEW: Pulmonary nontuberculous mycobacterial (NTM) infection is recognized as one of the most challenging infections to treat among cystic fibrosispatients. The source of NTM infection, modes of transmission, and exposure risks are poorly understood. Healthcare-associated transmission of Mycobacterium abscessus among cystic fibrosispatients has been suspected and is a growing concern for cystic fibrosis centers worldwide. This review describes our current understanding of prevention of healthcare-associated transmission of M. abscessus among patients with cystic fibrosis. RECENT FINDINGS: Multiple healthcare-associated outbreaks of M. abscessus among cystic fibrosispatients within cystic fibrosis care centers have been reported. The percentage of patients involved in the reported outbreaks, as well as the perceived impact of patient-to-patient transmission varies dramatically between the reporting centers and population surveys. Several groups have now proposed M. abscessus-specific measures to limit future outbreaks. SUMMARY: Improved NTM surveillance combined with a standardized, systematic approach to epidemiologic investigation of potential episodes of healthcare-associated transmission will help to reveal risk factors for NTM acquisition and inform future evidence-based infection prevention and control measures for patients with cystic fibrosis.
Authors: Arthur W Baker; Jason E Stout; Deverick J Anderson; Daniel J Sexton; Becky Smith; Rebekah W Moehring; Kirk Huslage; Christopher J Hostler; Sarah S Lewis Journal: Clin Infect Dis Date: 2021-08-02 Impact factor: 9.079
Authors: Rebecca M Davidson; Sophie E Nick; Sara M Kammlade; Sruthi Vasireddy; Natalia Weakly; Nabeeh A Hasan; L Elaine Epperson; Michael Strong; Jerry A Nick; Barbara A Brown-Elliott; Jason E Stout; Sarah S Lewis; Richard J Wallace; Arthur W Baker Journal: J Clin Microbiol Date: 2021-10-27 Impact factor: 11.677
Authors: Rebecca M Davidson; Nabeeh A Hasan; L Elaine Epperson; Jeanne B Benoit; Sara M Kammlade; Adrah R Levin; Vinicius Calado de Moura; Joshua Hunkins; Natalia Weakly; Sean Beagle; Scott D Sagel; Stacey L Martiniano; Max Salfinger; Charles L Daley; Jerry A Nick; Michael Strong Journal: Ann Am Thorac Soc Date: 2021-12
Authors: Jane E Gross; Silvia Caceres; Katie Poch; Nabeeh A Hasan; Rebecca M Davidson; L Elaine Epperson; Ettie Lipner; Charmie Vang; Jennifer R Honda; Matthew Strand; Michael Strong; Lisa Saiman; D Rebecca Prevots; Kenneth N Olivier; Jerry A Nick Journal: PLoS One Date: 2021-12-20 Impact factor: 3.240
Authors: Florian P Maurer; Michael Hogardt; Nils Wetzstein; Margo Diricks; Thomas A Kohl; Thomas A Wichelhaus; Sönke Andres; Laura Paulowski; Carsten Schwarz; Astrid Lewin; Jan Kehrmann; Barbara C Kahl; Karl Dichtl; Christian Hügel; Olaf Eickmeier; Christina Smaczny; Annika Schmidt; Stefan Zimmermann; Lutz Nährlich; Sylvia Hafkemeyer; Stefan Niemann Journal: Microbiol Spectr Date: 2022-08-08
Authors: Jerry A Nick; D Rebecca Prevots; Ettie M Lipner; James L Crooks; Joshua French; Michael Strong Journal: J Expo Sci Environ Epidemiol Date: 2021-07-03 Impact factor: 5.563