| Literature DB >> 31435919 |
K Kalishwaralal1,2, G Luboshits2,3, M A Firer4,5,6.
Abstract
Peptide-drug conjugates (PDCs) are being developed for the targeted delivery of drugs to cancer cells. Several approaches are being followed to enhance their stability in biological solutions. Here we describe an effective method to easily couple PDCs to polyethylene-coated gold nanoparticles. We also outline analytical methods to validate the coupling and assays to measure the stability and cytotoxic efficacy of the conjugates.Entities:
Keywords: Gold nanoparticles; Peptide–drug conjugates; Targeted drug delivery
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Year: 2020 PMID： 31435919 DOI： 10.1007/978-1-4939-9798-5_6
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745