| Literature DB >> 31435887 |
Kirsha S Gordon1,2, Kathleen McGinnis3, Cecilia Dao4, Christopher T Rentsch3,5, Aeron Small4, Rachel Vickers Smith6, Rachel L Kember7,8, Joel Gelernter3,4, Henry R Kranzler8,9, Kendall J Bryant10, Janet P Tate3,4, Amy C Justice3,4.
Abstract
We contrast three types of abstinence: quit after alcohol associated problems (Q-AP), quit for other reasons (Q-OR), and lifetime abstainer (LTA). We summarized the characteristics of people living with HIV (PLWH), and matched uninfected individuals, by levels of alcohol use and types of abstinence. We then identified factors that differentiate abstinence and determined whether the association with an alcohol biomarker or a genetic polymorphism is improved by differentiating abstinence. Among abstainers, 34% of PLWH and 38% of uninfected were Q-AP; 53% and 53% were Q-OR; and 12% and 10% were LTA. Logistic regression models found smoking, alcohol, cocaine, and hepatitis C increased odds of Q-AP, whereas smoking and marijuana decreased odds of LTA. Differentiating types of abstinence improved association. Q-APs and LTAs can be readily differentiated by an alcohol biomarker and genetic polymorphism. Differentiating type of abstinence may enhance understanding of alcohol health effects.Entities:
Keywords: ADH1B; Alcohol use disorder; HIV; Phosphatidylethanol; Veterans
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Year: 2020 PMID： 31435887 PMCID： PMC6994373 DOI： 10.1007/s10461-019-02638-x
Source DB: PubMed Journal: AIDS Behav ISSN： 1090-7165