Literature DB >> 3143580

Rapid method for determining the beta-lactamase-inducing potency of drugs.

H Mett1, I Oberkirch, B Schacher.   

Abstract

A rapid semiquantitative method for determining the beta-lactamase inducing potency of drugs was developed. Bacteria carrying a gene for inducible beta-lactamase expression were inoculated at a concentration of 10(8) CFU/ml into microtiter plates for determination of MICs, which were recorded after 4 h of incubation. A suitable chromogenic beta-lactamase substrate was then added, and after incubation for another 3 h colour changes were monitored.

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Year:  1988        PMID： 3143580     DOI： 10.1007/bf01964250

Source DB:  PubMed          Journal:  Eur J Clin Microbiol Infect Dis        ISSN： 0934-9723            Impact factor:   3.267


  16 in total

1.  Beta-lactamase assays.

Authors:  G W Ross; C H O'Callaghan
Journal:  Methods Enzymol       Date:  1975       Impact factor: 1.600

2.  Induction of the beta-lactamases of a strain of Pseudomonas aeruginosa, Morganella morganii and Enterobacter cloacae.

Authors:  T H Farmer; C Reading
Journal:  J Antimicrob Chemother       Date:  1987-03       Impact factor: 5.790

3.  Mutant of Pseudomonas aeruginosa 18S that synthesizes type Id beta-lactamase constitutively.

Authors:  F Flett; N A Curtis; M H Richmond
Journal:  J Bacteriol       Date:  1976-09       Impact factor: 3.490

4.  Selection and properties of Pseudomonas aeruginosa variants resistant to beta-lactam antibiotics.

Authors:  W Cullman; K H Büscher; W Dick
Journal:  Eur J Clin Microbiol       Date:  1987-08       Impact factor: 3.267

5.  Inactivation of the ampD gene causes semiconstitutive overproduction of the inducible Citrobacter freundii beta-lactamase.

Authors:  F Lindberg; S Lindquist; S Normark
Journal:  J Bacteriol       Date:  1987-05       Impact factor: 3.490

6.  A second regulatory gene, blaR1, encoding a potential penicillin-binding protein required for induction of beta-lactamase in Bacillus licheniformis.

Authors:  T Kobayashi; Y F Zhu; N J Nicholls; J O Lampen
Journal:  J Bacteriol       Date:  1987-09       Impact factor: 3.490

7.  Investigations on beta-lactamase stability of recently developed beta-lactam compounds: study of enzyme kinetics.

Authors:  W Cullmann; W Dick
Journal:  Zentralbl Bakteriol Mikrobiol Hyg A       Date:  1983-05

8.  In vitro antagonism of beta-lactam antibiotics by cefoxitin.

Authors:  C C Sanders; W E Sanders; R V Goering
Journal:  Antimicrob Agents Chemother       Date:  1982-06       Impact factor: 5.191

Review 9.  beta-Lactamase inhibitors.

Authors:  S J Cartwright; S G Waley
Journal:  Med Res Rev       Date:  1983 Oct-Dec       Impact factor: 12.944

10.  Interaction of the novel penem CGP 31 608 and its enantiomer with type Id beta-lactamase and penicillin-binding proteins.

Authors:  H Mett; B Schacher; P Schneider; O Zak
Journal:  Eur J Clin Microbiol       Date:  1987-12       Impact factor: 3.267
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