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Literature DB >> 3143549

Preliminary evaluation of the effect of GABA and phosphatidylserine in epileptic patients.

C Loeb¹, E Benassi, G P Bo, L Cocito, M Maffini, P Scotto.

Abstract

The effect of the combined administration of gamma-aminobutyric acid (GABA) and phosphatidylserine was evaluated in a pilot study of 42 patients with drug-resistant epilepsy. The group included patients with complex partial seizures, simple partial seizures and absence seizures. Patients with complex partial seizures and simple partial seizures showed no significant improvement; on the other hand, there was a remarkable decrease in absence seizures, linearly related to the dose of GABA and phosphatidylserine. Side effects occurred in 9 patients and were usually mild.

Entities: Chemical Disease Species

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Year: 1987 PMID： 3143549 DOI： 10.1016/0920-1211(87)90043-x

Source DB: PubMed Journal: Epilepsy Res ISSN： 0920-1211 Impact factor: 3.045

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Cited

12 in total

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6. Homotaurine Treatment Enhances CD4⁺ and CD8⁺ Regulatory T Cell Responses and Synergizes with Low-Dose Anti-CD3 to Enhance Diabetes Remission in Type 1 Diabetic Mice.

Authors: Jide Tian; Hoa Dang; Karen Anne O'Laco; Min Song; Bryan-Clement Tiu; Spencer Gilles; Christina Zakarian; Daniel L Kaufman
Journal: Immunohorizons Date: 2019-10-21

Preliminary evaluation of the effect of GABA and phosphatidylserine in epileptic patients.

1. Oral GABA treatment downregulates inflammatory responses in a mouse model of rheumatoid arthritis.

2. Combining antigen-based therapy with GABA treatment synergistically prolongs survival of transplanted ß-cells in diabetic NOD mice.

3. γ-Aminobutyric acid regulates both the survival and replication of human β-cells.

4. Combined therapy with GABA and proinsulin/alum acts synergistically to restore long-term normoglycemia by modulating T-cell autoimmunity and promoting β-cell replication in newly diabetic NOD mice.

5. Mining of a phospholipase D and its application in enzymatic preparation of phosphatidylserine.

6. Homotaurine Treatment Enhances CD4⁺ and CD8⁺ Regulatory T Cell Responses and Synergizes with Low-Dose Anti-CD3 to Enhance Diabetes Remission in Type 1 Diabetic Mice.

7. GABA_A-Receptor Agonists Limit Pneumonitis and Death in Murine Coronavirus-Infected Mice.

8. Molecular cloning of the phospholipase D gene from Streptomyces sp. YU100 and its expression in Escherichia coli.

9. Emerging Roles for Microglial Phagocytic Signaling in Epilepsy.

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