Literature DB >> 31435182

Manual and Automated Procedures for Compiling a Very Large Sample of Centenarian Pedigrees.

Giacomo Nebbia1, Lisa Nussbaum2, Annie Helmkamp3, Stacy Andersen3, Thomas Perls3, Paola Sebastiani4.   

Abstract

A large portion of the baby boomer population will live beyond the age of 90 years and entitlement programs and various insurance products have thusly become interested in longevity risk. Beyond cohort life table predictions, actuaries have little to go on in determining which individuals or portions of populations are at increased risk of living to 90 or 100 or even older. We and others have noted strong familial risk for living beyond the oldest one percentile of survival and we developed an algorithm that uses information about relatives' longevity to compute the chance of an individual surviving to extreme old age. An important step of this work is to compile large samples of pedigrees with and without long lived family members. Here, we describe our process of hand-curation of centenarian pedigrees and software that we have developed for the automated construction of such pedigrees using internet-based resources that can support the manual process.

Entities:  

Keywords:  centenarians; human longevity; multigeneration pedigree; record linkage

Year:  2018        PMID: 31435182      PMCID: PMC6703835          DOI: 10.1080/10920277.2018.1462716

Source DB:  PubMed          Journal:  N Am Actuar J        ISSN: 1092-0277


  7 in total

1.  Siblings of centenarians live longer.

Authors:  T T Perls; E Bubrick; C G Wager; J Vijg; L Kruglyak
Journal:  Lancet       Date:  1998-05-23       Impact factor: 79.321

2.  Life-long sustained mortality advantage of siblings of centenarians.

Authors:  Thomas T Perls; John Wilmoth; Robin Levenson; Maureen Drinkwater; Melissa Cohen; Hazel Bogan; Erin Joyce; Stephanie Brewster; Louis Kunkel; Annibale Puca
Journal:  Proc Natl Acad Sci U S A       Date:  2002-06-11       Impact factor: 11.205

3.  Increasing Sibling Relative Risk of Survival to Older and Older Ages and the Importance of Precise Definitions of "Aging," "Life Span," and "Longevity".

Authors:  Paola Sebastiani; Lisa Nussbaum; Stacy L Andersen; Mara J Black; Thomas T Perls
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2015-03-26       Impact factor: 6.053

4.  Predictors of Exceptional Longevity: Effects of Early-Life and Midlife Conditions, and Familial Longevity.

Authors:  Leonid A Gavrilov; Natalia S Gavrilova
Journal:  N Am Actuar J       Date:  2015

5.  Familial Risk for Exceptional Longevity.

Authors:  Paola Sebastiani; Stacy L Andersen; Avery I McIntosh; Lisa Nussbaum; Meredith D Stevenson; Leslie Pierce; Samantha Xia; Kelly Salance; Thomas T Perls
Journal:  N Am Actuar J       Date:  2015-10-07

6.  The genetics of extreme longevity: lessons from the new England centenarian study.

Authors:  Paola Sebastiani; Thomas T Perls
Journal:  Front Genet       Date:  2012-11-30       Impact factor: 4.599

  7 in total

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