Jean-Francois Esculier1, Michael Jarrett2, Natasha M Krowchuk1, Alexander Rauscher3, Vanessa Wiggermann3, Jack E Taunton4, David R Wilson5, Anthony A Gatti6, Michael A Hunt7. 1. Department of Physical Therapy, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada. 2. Population Data BC, University of British Columbia, Vancouver, BC, Canada. 3. UBC MRI Research Centre, University of British Columbia, Vancouver, BC, Canada; Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada; Department of Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada. 4. Department of Family Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada. 5. Department of Orthopaedics and Centre for Hip Health and Mobility, University of British Columbia, Vancouver, BC, Canada; Vancouver Coastal Health Research Institute, Vancouver, BC, Canada. 6. School of Rehabilitation Sciences, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada; NeuralSeg Ltd, Hamilton, ON, Canada. 7. Department of Physical Therapy, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada. Electronic address: michael.hunt@ubc.ca.
Abstract
OBJECTIVE: Running is an easy way of meeting physical activity recommendations for individuals with knee osteoarthritis (KOA); however, it remains unknown how their cartilage reacts to running. The objective of this pilot study was to compare the effects of 30 min of running on T2 and T1ρ relaxation times of tibiofemoral cartilage in female runners with and without KOA. METHODS: Ten female runners with symptomatic KOA (mean age 52.6 ± 7.6 years) and 10 without KOA (mean age 52.5 ± 7.8 years) ran for 30 min on a treadmill. Tibiofemoral cartilage T2 and T1ρ relaxation times were measured using magnetic resonance imaging prior to and immediately after the bout of running. Repeated-measures analyses of covariance (ANCOVA) were conducted to examine between-group differences across scanning times. RESULTS: No Group × Time interactions were found for T2 (P ≥ 0.076) or T1ρ (P ≥ 0.288) relaxation times. However, runners with KOA showed increased T2 values compared with pre-running in the medial and lateral femur 55 min post-running (5.4 to 5.5%, P < 0.022) and in all four tibiofemoral compartments 90 min post-running (6.9 to 11.1%, P < 0.01). A significant group effect was found for T1ρ in the medial femur, with greater values in those with KOA compared with controls. CONCLUSION: While Group × Time interactions in T2 and T1ρ relaxation times remained statistically insignificant, the observed significant increases in T2 in runners with tibiofemoral osteoarthritis TFOA may suggest slower and continuing changes in the cartilage and thus a need for longer recovery after running. Future research should investigate the effects of repeated exposure to running.
OBJECTIVE: Running is an easy way of meeting physical activity recommendations for individuals with knee osteoarthritis (KOA); however, it remains unknown how their cartilage reacts to running. The objective of this pilot study was to compare the effects of 30 min of running on T2 and T1ρ relaxation times of tibiofemoral cartilage in female runners with and without KOA. METHODS: Ten female runners with symptomatic KOA (mean age 52.6 ± 7.6 years) and 10 without KOA (mean age 52.5 ± 7.8 years) ran for 30 min on a treadmill. Tibiofemoral cartilage T2 and T1ρ relaxation times were measured using magnetic resonance imaging prior to and immediately after the bout of running. Repeated-measures analyses of covariance (ANCOVA) were conducted to examine between-group differences across scanning times. RESULTS: No Group × Time interactions were found for T2 (P ≥ 0.076) or T1ρ (P ≥ 0.288) relaxation times. However, runners with KOA showed increased T2 values compared with pre-running in the medial and lateral femur 55 min post-running (5.4 to 5.5%, P < 0.022) and in all four tibiofemoral compartments 90 min post-running (6.9 to 11.1%, P < 0.01). A significant group effect was found for T1ρ in the medial femur, with greater values in those with KOA compared with controls. CONCLUSION: While Group × Time interactions in T2 and T1ρ relaxation times remained statistically insignificant, the observed significant increases in T2 in runners with tibiofemoral osteoarthritis TFOA may suggest slower and continuing changes in the cartilage and thus a need for longer recovery after running. Future research should investigate the effects of repeated exposure to running.
Authors: Hollis A Crowder; Valentina Mazzoli; Marianne S Black; Lauren E Watkins; Feliks Kogan; Brian A Hargreaves; Marc E Levenston; Garry E Gold Journal: J Orthop Res Date: 2021-02-03 Impact factor: 3.494
Authors: Michaela C M Khan; James O'Donovan; Jesse M Charlton; Jean-Sébastien Roy; Michael A Hunt; Jean-Francois Esculier Journal: Sports Med Date: 2021-09-03 Impact factor: 11.928
Authors: Jean-Francois Esculier; Manuela Besomi; Danilo de Oliveira Silva; Samuele Passigli; Michael Skovdal Rathleff; Marienke Van Middelkoop; Christian Barton; Michael J Callaghan; Matthew S Harkey; Alison M Hoens; Natasha M Krowchuk; Anthony Teoli; Bill Vicenzino; Richard W Willy; Michael A Hunt Journal: Orthop J Sports Med Date: 2022-09-30