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Literature DB >> 3143313

Randomised controlled trials of phenobarbitone and valproate in febrile convulsions.

Abstract

Results from British trials of phenobarbitone and valproate for the prophylactic treatment of febrile convulsions were pooled and analysed on an intention to treat basis. The overall odds ratio for phenobarbitone was 0.8 and for valproate 1.42. Neither result was significant. Neither treatment can be recommended in the light of experience.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1988 PMID： 3143313 PMCID： PMC1779011 DOI： 10.1136/adc.63.10.1189

Source DB: PubMed Journal: Arch Dis Child ISSN： 0003-9888 Impact factor: 3.791

6 in total

1. Overview of randomised trials of diuretics in pregnancy.

Authors: R Collins; S Yusuf; R Peto
Journal: Br Med J (Clin Res Ed) Date: 1985-01-05

2. Failure of phenobarbitone to prevent febrile convulsions.

Authors: J Z Heckmatt; A B Houston; D J Clow; J B Strephenson; K L Dodd; G T Lealman; R W Logan
Journal: Br Med J Date: 1976-03-06

3. Placebo-controlled study of phenobarbitone and phenytoin in the prophylaxis of febrile convulsions.

Authors: C J Bacon; A M Hierons; J C Mucklow; J K Webb; M D Rawlins; D Weightman
Journal: Lancet Date: 1981-09-19 Impact factor: 79.321

4. Sodium valproate in the prophylaxis of simple febrile convulsions.

Authors: A J Williams; L G Evans-Jones; A D Kindley; P J Groom
Journal: Clin Pediatr (Phila) Date: 1979-07 Impact factor: 1.168

5. Successful prophylaxis against febrile convulsions with valproic acid or phenobarbitone.

Authors: S J Wallace; J A Smith
Journal: Br Med J Date: 1980-02-09

6. Continuous sodium valproate or phenobarbitone in the prevention of 'simple' febrile convulsions. Comparison by a double-blind trial.

Authors: E Ngwane; B Bower
Journal: Arch Dis Child Date: 1980-03 Impact factor: 3.791

6 in total

14 in total

6. Guidelines for the management of convulsions with fever. Joint Working Group of the Research Unit of the Royal College of Physicians and the British Paediatric Association.

Authors:
Journal: BMJ Date: 1991-09-14

Review 10. Febrile seizures: an update.

Authors: C Waruiru; R Appleton
Journal: Arch Dis Child Date: 2004-08 Impact factor: 3.791

Randomised controlled trials of phenobarbitone and valproate in febrile convulsions.

1. Overview of randomised trials of diuretics in pregnancy.

2. Failure of phenobarbitone to prevent febrile convulsions.

3. Placebo-controlled study of phenobarbitone and phenytoin in the prophylaxis of febrile convulsions.

4. Sodium valproate in the prophylaxis of simple febrile convulsions.

5. Successful prophylaxis against febrile convulsions with valproic acid or phenobarbitone.

6. Continuous sodium valproate or phenobarbitone in the prevention of 'simple' febrile convulsions. Comparison by a double-blind trial.

Review 1. Evidence based paediatrics: Evidence based management of seizures associated with fever.

Review 2. An evidence-based approach to managing seizures associated with fever in children.

Review 3. Phenobarbitone and febrile convulsions.

4. Convulsions in the older infant.

5. Febrile convulsions.

6. Guidelines for the management of convulsions with fever. Joint Working Group of the Research Unit of the Royal College of Physicians and the British Paediatric Association.

Review 7. Valproate as a mainstay of therapy for pediatric epilepsy.

Review 8. Prophylactic drug management for febrile seizures in children.

Review 9. Pharmacological and therapeutic properties of valproate: a summary after 35 years of clinical experience.

Review 10. Febrile seizures: an update.