Literature DB >> 31432308

NFIC promotes the vitality and osteogenic differentiation of rat dental follicle cells.

Fuping Zhang1,2, Min Liang1,2, Chuanjiang Zhao1,2, Yun Fu1,2, Shaojie Yu3,4.   

Abstract

Nuclear factor I-C (NFIC) plays critical roles in the regulation of tooth development by influencing the biological behaviors of stem cells in the dental germ. This study aimed to investigate the effect of NFIC on the vitality and osteogenic/cementogenic differentiation of rat dental follicle cells (DFCs). DFCs were isolated from dental follicles in the first molars of neonatal rats. DFCs expressed mesenchymal stromal cell markers CD29, CD44 and CD90 and had capabilities for self-renewal and multipotent differentiation. Overexpression of NFIC promoted the proliferation of DFCs without markedly influencing the apoptosis of DFCs. Moreover, NFIC increased alkaline phosphatase (ALP) activity in DFCs and upregulated the mRNA levels of osteogenic-related markers, namely, collagen type I (Col I), Runt-related transcription factor 2 (Runx2) and ALP, as well as β-catenin. In contrast, silencing NFIC by siRNA increased the apoptosis of DFCs and downregulated the expression of osteogenic-related markers. In conclusion, these results suggested that upregulation of NFIC may promote the proliferation and osteogenic/cementogenic differentiation of DFCs.

Entities:  

Keywords:  Cell apoptosis; Cell vitality; Dental follicle cells; NFIC; Osteogenic/cementogenic differentiation

Mesh：

Substances：

Year:  2019        PMID： 31432308     DOI： 10.1007/s10735-019-09841-z

Source DB:  PubMed          Journal:  J Mol Histol        ISSN： 1567-2379            Impact factor:   2.611


  35 in total

Review 1.  Roles of the NFI/CTF gene family in transcription and development.

Authors:  R M Gronostajski
Journal:  Gene       Date:  2000-05-16       Impact factor: 3.688

2.  Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement.

Authors:  M Dominici; K Le Blanc; I Mueller; I Slaper-Cortenbach; Fc Marini; Ds Krause; Rj Deans; A Keating; Dj Prockop; Em Horwitz
Journal:  Cytotherapy       Date:  2006       Impact factor: 5.414

3.  Dental follicle progenitor cell heterogeneity in the developing mouse periodontium.

Authors:  Xianghong Luan; Yoshihiro Ito; Smit Dangaria; Thomas G H Diekwisch
Journal:  Stem Cells Dev       Date:  2006-08       Impact factor: 3.272

4.  Nfic gene disruption inhibits differentiation of odontoblasts responsible for root formation and results in formation of short and abnormal roots in mice.

Authors:  Joo-Cheol Park; Yeek Herr; Heung-Joong Kim; Richard M Gronostajski; Moon-Il Cho
Journal:  J Periodontol       Date:  2007-09       Impact factor: 6.993

5.  Disruption of Nfic causes dissociation of odontoblasts by interfering with the formation of intercellular junctions and aberrant odontoblast differentiation.

Authors:  Tae-Yeon Lee; Dong-Seol Lee; Hyun-Man Kim; Jea Seung Ko; Richard M Gronostajski; Moon-Il Cho; Ho-Hyun Son; Joo-Cheol Park
Journal:  J Histochem Cytochem       Date:  2009-01-19       Impact factor: 2.479

6.  Establishment of immortalized dental follicle cells for generating periodontal ligament in vivo.

Authors:  T Yokoi; M Saito; T Kiyono; S Iseki; K Kosaka; E Nishida; T Tsubakimoto; H Harada; K Eto; T Noguchi; T Teranaka
Journal:  Cell Tissue Res       Date:  2006-09-30       Impact factor: 5.249

7.  Isolation of precursor cells (PCs) from human dental follicle of wisdom teeth.

Authors:  C Morsczeck; W Götz; J Schierholz; F Zeilhofer; U Kühn; C Möhl; C Sippel; K H Hoffmann
Journal:  Matrix Biol       Date:  2005-02-12       Impact factor: 11.583

8.  Nuclear factor I-C is essential for odontogenic cell proliferation and odontoblast differentiation during tooth root development.

Authors:  Dong-Seol Lee; Jong-Tae Park; Hyun-Man Kim; Jea Seung Ko; Ho-Hyun Son; Richard M Gronostajski; Moon-Il Cho; Pill-Hoon Choung; Joo-Cheol Park
Journal:  J Biol Chem       Date:  2009-04-22       Impact factor: 5.157

9.  Differentiation of stem cells in the dental follicle.

Authors:  S Yao; F Pan; V Prpic; G E Wise
Journal:  J Dent Res       Date:  2008-08       Impact factor: 6.116

10.  Research on promoting periodontal regeneration with human basic fibroblast growth factor-modified bone marrow mesenchymal stromal cell gene therapy.

Authors:  Zhen Tan; Qing Zhao; Ping Gong; Yang Wu; Na Wei; Quan Yuan; Chuan Wang; Dapeng Liao; Hua Tang
Journal:  Cytotherapy       Date:  2009       Impact factor: 5.414
View more
  3 in total

1.  Transcription factor NFIC functions as a tumor suppressor in lung squamous cell carcinoma progression by modulating lncRNA CASC2.

Authors:  Hong Zhang; Zhilin Luo; JianMing Tang; Jie Tian; Yajie Xiao; Chao Sun; Tianhu Wang
Journal:  Cell Cycle       Date:  2022-01-05       Impact factor: 4.534

2.  Downregulation of miR-184 facilitates osseous differentiation in periodontal ligament stem cells by modulating nuclear factor I-C.

Authors:  Chunying Li; Guanglin Duan; Yaopu Feng
Journal:  J Dent Sci       Date:  2020-10-12       Impact factor: 2.080

3.  In vivo cell proliferation analysis and cell-tracing reveal the global cellular dynamics of periodontal ligament cells under mechanical-loading.

Authors:  Masaru Mizukoshi; Masaru Kaku; Lay Thant; Kohei Kitami; Moe Arai; Isao Saito; Katsumi Uoshima
Journal:  Sci Rep       Date:  2021-05-07       Impact factor: 4.379
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.