| Literature DB >> 31432151 |
Shizhen Zhang1, Qiuping Mo2, Xiaochen Wang1.
Abstract
The high mobility group A2 (HMGA2) protein is a non‑histone architectural transcription factor that modulates the transcription of several genes by binding to AT‑rich sequences in the minor groove of B‑form DNA and alters the chromatin structure. As a result, HMGA2 influences a variety of biological processes, including the cell cycle process, DNA damage repair process, apoptosis, senescence, epithelial‑mesenchymal transition and telomere restoration. In addition, the overexpression of HMGA2 is a feature of malignancy, and its elevated expression in human cancer predicts the efficacy of certain chemotherapeutic agents. Accumulating evidence has suggested that the detection of HMGA2 can be used as a routine procedure in clinical tumour analysis.Entities:
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Year: 2019 PMID： 31432151 DOI： 10.3892/ijo.2019.4856
Source DB: PubMed Journal: Int J Oncol ISSN： 1019-6439 Impact factor: 5.650