Literature DB >> 31431841

Eye-of-the-tiger Sign in Neurodegeneration with Brain Iron Accumulation.

Madeline Goldberg1, Khizar Malik2, Rekha Jiswant1, Aunali S Khaku2.   

Abstract

A 68-year-old male patient presented to the neurology clinic with tremor, lightheadedness, and a history of syncope. Exam showed mild Parkinsonism. Neuroimaging revealed symmetric lesions of the globus pallidus (the eye-of-the-tiger sign) concerning for neurodegeneration with brain iron accumulation (NBIA). Genetic panel for NBIA was ordered, specifically pantothenate kinase-associated neurodegeneration (PKAN), including pantothenate kinase 2 (PanK2) - the genetic marker for the pantothenate kinase enzyme.

Entities:  

Keywords:  eye-of-the-tiger-sign; hallervorden-spatz; mri; nbia

Year:  2019        PMID： 31431841      PMCID： PMC6695239          DOI： 10.7759/cureus.4936

Source DB:  PubMed          Journal:  Cureus        ISSN： 2168-8184


  2 in total

1.  Genotypic and phenotypic spectrum of PANK2 mutations in patients with neurodegeneration with brain iron accumulation.

Authors:  Monika B Hartig; Konstanze Hörtnagel; Barbara Garavaglia; Giovanna Zorzi; Tomasz Kmiec; Thomas Klopstock; Kevin Rostasy; Marina Svetel; Vladimir S Kostic; Markus Schuelke; Evelyn Botz; Adolf Weindl; Ivana Novakovic; Nardo Nardocci; Holger Prokisch; Thomas Meitinger
Journal:  Ann Neurol       Date:  2006-02       Impact factor: 10.422

2.  T2* and FSE MRI distinguishes four subtypes of neurodegeneration with brain iron accumulation.

Authors:  A McNeill; D Birchall; S J Hayflick; A Gregory; J F Schenk; E A Zimmerman; H Shang; H Miyajima; P F Chinnery
Journal:  Neurology       Date:  2008-04-29       Impact factor: 9.910
  2 in total
  1 in total

1.  Intellectual Disability, Falls and Gait Disturbances: A Misdiagnosis.

Authors:  Noel Lorenzo Villalba; Santiago Díaz Nicolas; Maria Belen Alonso Ortiz; Zaida Cordoba Sosa; Saturnino Suárez Ortega; Abrar-Ahmad Zulfiqar
Journal:  Eur J Case Rep Intern Med       Date:  2020-02-13
  1 in total

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