Literature DB >> 31430155

Dehydroabietylamine Ureas and Thioureas as Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Enhance the Antitumor Effect of Temozolomide on Glioblastoma Cells.

Kseniya Kovaleva1,2, Olga Oleshko2, Evgeniya Mamontova3, Olga Yarovaya1,2, Olga Zakharova3, Alexandra Zakharenko3, Alena Kononova2, Nadezhda Dyrkheeva3, Sergey Cheresiz2,4, Andrey Pokrovsky2, Olga Lavrik2,3, Nariman Salakhutdinov1,2.   

Abstract

A new class of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors was found among resin acid derivatives. Several novel ureas and thioureas derived from dehydroabietylamine were synthesized and tested for TDP1 inhibition. The synthesized compounds showed IC50 values in the range of 0.1 to 3.7 μM and demonstrated low cytotoxicity against the human tumor cell lines U-937, U-87MG, MDA-MB, SK-Mel8, A-549, MCF7, T98G, and SNB19. Several compounds showed enhancement of the cytotoxic activity of the alkylating agent temozolomide, which is used as a first line therapy against glioblastoma (GBM), in the GBM cell lines U-87MG and SNB19.

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Year:  2019        PMID： 31430155     DOI： 10.1021/acs.jnatprod.8b01095

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  8 in total

1.  Dehydroabietylamine-based thiazolidin-4-ones and 2-thioxoimidazolidin-4-ones as novel tyrosyl-DNA phosphodiesterase 1 inhibitors.

Authors:  Kseniya Kovaleva; Evgeniya Mamontova; Olga Yarovaya; Olga Zakharova; Alexandra Zakharenko; Olga Lavrik; Nariman Salakhutdinov
Journal:  Mol Divers       Date:  2020-08-24       Impact factor: 2.943

2.  The influence of an enamine usnic acid derivative (a tyrosyl-DNA phosphodiesterase 1 inhibitor) on the therapeutic effect of topotecan against transplanted tumors in vivo.

Authors:  V P Nikolin; N A Popova; V I Kaledin; O A Luzina; A L Zakharenko; N F Salakhutdinov; O I Lavrik
Journal:  Clin Exp Metastasis       Date:  2021-08-09       Impact factor: 5.150

3.  Promising New Inhibitors of Tyrosyl-DNA Phosphodiesterase I (Tdp 1) Combining 4-Arylcoumarin and Monoterpenoid Moieties as Components of Complex Antitumor Therapy.

Authors:  Tatyana M Khomenko; Alexandra L Zakharenko; Arina A Chepanova; Ekaterina S Ilina; Olga D Zakharova; Vasily I Kaledin; Valeriy P Nikolin; Nelly A Popova; Dina V Korchagina; Jóhannes Reynisson; Raina Chand; Daniel M Ayine-Tora; Jinal Patel; Ivanhoe K H Leung; Konstantin P Volcho; Nariman F Salakhutdinov; Olga I Lavrik
Journal:  Int J Mol Sci       Date:  2019-12-23       Impact factor: 5.923

4.  Novel Tdp1 Inhibitors Based on Adamantane Connected with Monoterpene Moieties via Heterocyclic Fragments.

Authors:  Aldar A Munkuev; Evgenii S Mozhaitsev; Arina A Chepanova; Evgeniy V Suslov; Dina V Korchagina; Olga D Zakharova; Ekaterina S Ilina; Nadezhda S Dyrkheeva; Alexandra L Zakharenko; Jóhannes Reynisson; Konstantin P Volcho; Nariman F Salakhutdinov; Olga I Lavrik
Journal:  Molecules       Date:  2021-05-24       Impact factor: 4.411

5.  Design, Synthesis, and Molecular Docking Study of New Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Inhibitors Combining Resin Acids and Adamantane Moieties.

Authors:  Kseniya Kovaleva; Olga Yarovaya; Konstantin Ponomarev; Sergey Cheresiz; Amirhossein Azimirad; Irina Chernyshova; Alexandra Zakharenko; Vasily Konev; Tatiana Khlebnikova; Evgenii Mozhaytsev; Evgenii Suslov; Dmitry Nilov; Vytas Švedas; Andrey Pokrovsky; Olga Lavrik; Nariman Salakhutdinov
Journal:  Pharmaceuticals (Basel)       Date:  2021-05-01

6.  Synthesis, antitumor and DNA cleavage activities of a novel class of dehydroabietylamine derivatives.

Authors:  Jincai Li; Chaoxiang Liu
Journal:  Heliyon       Date:  2020-02-13

7.  A Dual-Sensor-Based Screening System for In Vitro Selection of TDP1 Inhibitors.

Authors:  Ann-Katrine Jakobsen; Josephine Geertsen Keller; María Gonzalez; Endika Martin-Encinas; Francisco Palacios; Concepcion Alonso; Birgitta Ruth Knudsen; Magnus Stougaard
Journal:  Sensors (Basel)       Date:  2021-07-15       Impact factor: 3.576

8.  Pyranodipyran Derivatives with Tyrosyl DNA Phosphodiesterase 1 Inhibitory Activities and Fluorescent Properties from Aspergillus sp. EGF 15-0-3.

Authors:  Xia Wei; Fang-Ting Wang; Mei-Xia Si-Tu; Hao Fan; Jin-Shan Hu; Hao Yang; Shan-Yue Guan; Lin-Kun An; Cui-Xian Zhang
Journal:  Mar Drugs       Date:  2022-03-17       Impact factor: 5.118
  8 in total

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