OBJECTIVE: To determine whether exposure to polychlorinated biphenyls (PCBs) or dichlorodiphenyl dichloroethene (DDE), either transplacentally or through breast feeding, affected scores on the Bayley Scales of Infant Development at 6 or 12 months of age. DESIGN: Cohort followed from birth to 1 year of age. SETTING: General community. PARTICIPANTS: Volunteer sample of 858 infants, of whom 802 had Bayley scores available at either 6 months or 12 months or both. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Bayley scales and chemical measurements were done independently. Higher transplacental exposure to PCBs was associated with lower psychomotor scores at both 6 and 12 months of age; the difference between the mean scores in the lowest and highest PCB groups was 7 points at 6 months and 8 points at 12 months. Higher transplacental exposure to DDE was associated with higher mental scores at 6 months of age (the difference between the mean scores in the lowest and highest DDE groups was 6 points), but no relationship was seen at 12 months. Exposure to either chemical through breast feeding was apparently unrelated to Bayley scores. CONCLUSIONS: Transplacental exposure to PCBs was associated with lower psychomotor scores. No deleterious effects were associated with breast feeding.
OBJECTIVE: To determine whether exposure to polychlorinated biphenyls (PCBs) or dichlorodiphenyl dichloroethene (DDE), either transplacentally or through breast feeding, affected scores on the Bayley Scales of Infant Development at 6 or 12 months of age. DESIGN: Cohort followed from birth to 1 year of age. SETTING: General community. PARTICIPANTS: Volunteer sample of 858 infants, of whom 802 had Bayley scores available at either 6 months or 12 months or both. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Bayley scales and chemical measurements were done independently. Higher transplacental exposure to PCBs was associated with lower psychomotor scores at both 6 and 12 months of age; the difference between the mean scores in the lowest and highest PCB groups was 7 points at 6 months and 8 points at 12 months. Higher transplacental exposure to DDE was associated with higher mental scores at 6 months of age (the difference between the mean scores in the lowest and highest DDE groups was 6 points), but no relationship was seen at 12 months. Exposure to either chemical through breast feeding was apparently unrelated to Bayley scores. CONCLUSIONS: Transplacental exposure to PCBs was associated with lower psychomotor scores. No deleterious effects were associated with breast feeding.
Authors: Alan S Brown; Keely Cheslack-Postava; Panu Rantakokko; Hannu Kiviranta; Susanna Hinkka-Yli-Salomäki; Ian W McKeague; Heljä-Marja Surcel; Andre Sourander Journal: Am J Psychiatry Date: 2018-08-16 Impact factor: 18.112
Authors: Brenda Eskenazi; Jonathan Chevrier; Lisa Goldman Rosas; Henry A Anderson; Maria S Bornman; Henk Bouwman; Aimin Chen; Barbara A Cohn; Christiaan de Jager; Diane S Henshel; Felicia Leipzig; John S Leipzig; Edward C Lorenz; Suzanne M Snedeker; Darwin Stapleton Journal: Environ Health Perspect Date: 2009-05-04 Impact factor: 9.031
Authors: Michael Goodman; Katherine Squibb; Eric Youngstrom; Laura Gutermuth Anthony; Lauren Kenworthy; Paul H Lipkin; Donald R Mattison; Judy S Lakind Journal: Environ Health Perspect Date: 2010-02-22 Impact factor: 9.031
Authors: Hye-Youn Park; June-Soo Park; Eva Sovcikova; Anton Kocan; Linda Linderholm; Ake Bergman; Tomas Trnovec; Irva Hertz-Picciotto Journal: Environ Health Perspect Date: 2009-05-20 Impact factor: 9.031