Remzi Bahşi1, Volkan Atmiş2, Tuğba Turgut3, Deniz Mut Sürmeli2, Çağlar Coşarderelioğlu2, Hande Selvi Öztorun2, Ahmet Yalçin2, Sevgi Aras2, Murat Varli2. 1. Department of Geriatrics, Ankara University School of Medicine, Hacettepe, Talatpaşa Blv No:82, Altındağ/Ankara, Turkey. drremzibahsi@gmail.com. 2. Department of Geriatrics, Ankara University School of Medicine, Hacettepe, Talatpaşa Blv No:82, Altındağ/Ankara, Turkey. 3. Department of Geriatrics, Antalya Education and Research Hospital, Antalya, Turkey.
Abstract
BACKGROUND: We aimed to investigate the effects of zoledronic acid treatment on daily living activities, cognitive functions, depression, muscle strength, and performance. METHODS: The study was conducted retrospectively. Bone mineral densitometry (BMD) values, Katz activities of daily living (ADL), Lawton-Brody instrumental activities of daily living (IADL), mini mental state examination (MMSE), geriatric depression scale (GDS), mini nutritional assessment (MNA), grip strength, and gait speed scores before and 6 months after zoledronic acid administration were compared. RESULTS: A total of 115 patients were included in the study. There was a significant increase in lumbar total (p < .001), femoral neck (p = .002), and femur total (p = .001) BMD values after zoledronic acid treatment. Significant decrease was found in MMSE (p = .016) and gait speed scores (p = .008) after zoledronic acid treatment, but no significant difference was found in terms of Katz ADL, Lawton-Brody IADL, MNA, GDS, and grip strength (p > .05). CONCLUSION: Our study indicated that zoledronic acid did not affect daily living activities, depression, and muscle strength. Although we have concluded that cognitive and muscle performance may be adversely affected by zoledronic acid treatment.
BACKGROUND: We aimed to investigate the effects of zoledronic acid treatment on daily living activities, cognitive functions, depression, muscle strength, and performance. METHODS: The study was conducted retrospectively. Bone mineral densitometry (BMD) values, Katz activities of daily living (ADL), Lawton-Brody instrumental activities of daily living (IADL), mini mental state examination (MMSE), geriatric depression scale (GDS), mini nutritional assessment (MNA), grip strength, and gait speed scores before and 6 months after zoledronic acid administration were compared. RESULTS: A total of 115 patients were included in the study. There was a significant increase in lumbar total (p < .001), femoral neck (p = .002), and femur total (p = .001) BMD values after zoledronic acid treatment. Significant decrease was found in MMSE (p = .016) and gait speed scores (p = .008) after zoledronic acid treatment, but no significant difference was found in terms of Katz ADL, Lawton-Brody IADL, MNA, GDS, and grip strength (p > .05). CONCLUSION: Our study indicated that zoledronic acid did not affect daily living activities, depression, and muscle strength. Although we have concluded that cognitive and muscle performance may be adversely affected by zoledronic acid treatment.
Authors: Steven Boonen; Jean-Yves Reginster; Jean-Marc Kaufman; Kurt Lippuner; Jose Zanchetta; Bente Langdahl; Rene Rizzoli; Stanley Lipschitz; Hans Peter Dimai; Richard Witvrouw; Erik Eriksen; Kim Brixen; Luis Russo; Frank Claessens; Philemon Papanastasiou; Oscar Antunez; Guoqin Su; Christina Bucci-Rechtweg; Josef Hruska; Elodie Incera; Dirk Vanderschueren; Eric Orwoll Journal: N Engl J Med Date: 2012-11-01 Impact factor: 91.245