Virgile Clergue-Duval1,2,3, Frank Questel4,5, Julien Azuar4,5, Claire Paquet5,6, Emmanuel Cognat5,6, Jihed Amami4, Mathieu Queneau7, Alexandra Dereux4,5, Thomas Barré4, Frank Bellivier4,5,8, Karim Farid5,9, Florence Vorspan4,5,8. 1. Département de Psychiatrie et de Médecine Addictologique, Groupe Hospitalier Saint-Louis Lariboisière Fernand-Widal, Hôpital Fernand Widal, Paris, France. virgile.clergue-duval@aphp.fr. 2. Inserm UMRS-1144 Optimisation thérapeutique en neuropsychopharmacologie, Université de Paris, Paris, France. virgile.clergue-duval@aphp.fr. 3. Faculté de Médecine, Université de Paris, 75475, Paris Cedex 10, France. virgile.clergue-duval@aphp.fr. 4. Département de Psychiatrie et de Médecine Addictologique, Groupe Hospitalier Saint-Louis Lariboisière Fernand-Widal, Hôpital Fernand Widal, Paris, France. 5. Inserm UMRS-1144 Optimisation thérapeutique en neuropsychopharmacologie, Université de Paris, Paris, France. 6. APHP, Centre de Neurologie Cognitive, Groupe Hospitalier Saint-Louis Lariboisière Fernand-Widal, Paris, France. 7. Service de médecine nucléaire, Centre Cardiologique du Nord, St-Denis, France. 8. Faculté de Médecine, Université de Paris, 75475, Paris Cedex 10, France. 9. Service de médecine nucléaire, CHU Martinique, Fort de France, Martinique, FWI, France.
Abstract
PURPOSE: Brain positron emission tomography using 18F-fluorodeoxyglucose (18FDG-PET) provides a metabolic assessment of brain function that is useful for differential diagnosis among several neurodegenerative diseases manifested by cognitive impairment (CI). The purpose of the study is to describe the pattern of 18FDG-PET abnormalities in patients with CI related to alcohol use disorder. METHODS: Patients admitted to the addiction medicine department of a university hospital in Paris between January 2017 and October 2018 with a confirmed diagnosis of alcohol-related cognitive impairment (ARCI) or Wernicke encephalopathy (WE) were included. Brain 18FDG-PET uptake was measured after at least 1 month of monitored abstinence from alcohol. Standardized uptake values were obtained for 13 regions of interest (ROI) and normalized to the pons. Individual patients' ROI Z-scores were calculated from healthy sex- and age-matched controls provided by Cortex ID software. RESULTS: Twenty-five patients were included in the analysis (20 males and 5 females; mean age 57.6 years (45-76 years old)). The group consisted of 19 ARCI and 6 WE cases. The mean hypometabolism was most severe in the prefrontal medial cortex (PFM) (- 2.80 (± 1.30)), the prefrontal lateral cortex (- 2.20 (± 1.35)), and the anterior cingulate cortex (- 2.24 (± 1.19)). Hypometabolism (Z-score < - 2) was most frequent in the PFM (72.0% of the sample, N = 18). Other regions were also affected (with 5.32/13 hypometabolic ROIs on average (SD = 4.16, range 0-13)). The Z-scores in the 13 ROIs did not differ significantly between the ARCI and WE patients (p ≥ 0.05). CONCLUSIONS: Predominant prefrontal and cingulate cortex hypometabolism was the most frequent brain 18FDG-PET pattern in our sample of patients with ARCI and WE.
PURPOSE: Brain positron emission tomography using 18F-fluorodeoxyglucose (18FDG-PET) provides a metabolic assessment of brain function that is useful for differential diagnosis among several neurodegenerative diseases manifested by cognitive impairment (CI). The purpose of the study is to describe the pattern of 18FDG-PET abnormalities in patients with CI related to alcohol use disorder. METHODS:Patients admitted to the addiction medicine department of a university hospital in Paris between January 2017 and October 2018 with a confirmed diagnosis of alcohol-related cognitive impairment (ARCI) or Wernicke encephalopathy (WE) were included. Brain 18FDG-PET uptake was measured after at least 1 month of monitored abstinence from alcohol. Standardized uptake values were obtained for 13 regions of interest (ROI) and normalized to the pons. Individual patients' ROI Z-scores were calculated from healthy sex- and age-matched controls provided by Cortex ID software. RESULTS: Twenty-five patients were included in the analysis (20 males and 5 females; mean age 57.6 years (45-76 years old)). The group consisted of 19 ARCI and 6 WE cases. The mean hypometabolism was most severe in the prefrontal medial cortex (PFM) (- 2.80 (± 1.30)), the prefrontal lateral cortex (- 2.20 (± 1.35)), and the anterior cingulate cortex (- 2.24 (± 1.19)). Hypometabolism (Z-score < - 2) was most frequent in the PFM (72.0% of the sample, N = 18). Other regions were also affected (with 5.32/13 hypometabolic ROIs on average (SD = 4.16, range 0-13)). The Z-scores in the 13 ROIs did not differ significantly between the ARCI and WE patients (p ≥ 0.05). CONCLUSIONS: Predominant prefrontal and cingulate cortex hypometabolism was the most frequent brain 18FDG-PET pattern in our sample of patients with ARCI and WE.
Authors: N D Volkow; G J Wang; J E Overall; R Hitzemann; J S Fowler; N Pappas; E Frecska; K Piscani Journal: Alcohol Clin Exp Res Date: 1997-10 Impact factor: 3.455
Authors: Andreas J Bartsch; György Homola; Armin Biller; Stephen M Smith; Heinz-Gerd Weijers; Gerhard A Wiesbeck; Mark Jenkinson; Nicola De Stefano; László Solymosi; Martin Bendszus Journal: Brain Date: 2007-01 Impact factor: 13.501
Authors: Lilja B Solnes; Krystyna M Jones; Steven P Rowe; Puskar Pattanayak; Abhinav Nalluri; Arun Venkatesan; John C Probasco; Mehrbod S Javadi Journal: J Nucl Med Date: 2017-02-16 Impact factor: 10.057