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Literature DB >> 3142840

Glidobactins A, B and C, new antitumor antibiotics. I. Production, isolation, chemical properties and biological activity.

M Oka¹, Y Nishiyama, S Ohta, H Kamei, M Konishi, T Miyaki, T Oki, H Kawaguchi.

Abstract

New antitumor antibiotic glidobactins A, B and C were isolated from the cultured broth of a gliding bacterium, Polyangium brachysporum sp. nov. No. K481-B101. They are novel molecules carrying the common cyclic tripeptide nucleus substituted with different alpha, beta, gamma, delta-unsaturated fatty acids. Glidobactins exhibit broad inhibitory activity against fungi and yeasts, and prolong the life span of mice inoculated with P388 leukemia cells.

Entities: Chemical Disease Species

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Year: 1988 PMID： 3142840 DOI： 10.7164/antibiotics.41.1331

Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649

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Cited

16 in total

1. Improvement of glidobactin A production by Polyangium brachysporum.

Authors: J A Titus; C A Roundy
Journal: J Ind Microbiol Date: 1990-11

2. N-acylation during glidobactin biosynthesis by the tridomain nonribosomal peptide synthetase module GlbF.

Authors: Heidi J Imker; Daniel Krahn; Jérôme Clerc; Markus Kaiser; Christopher T Walsh
Journal: Chem Biol Date: 2010-10-29

3. Synthetic and structural studies on syringolin A and B reveal critical determinants of selectivity and potency of proteasome inhibition.

Authors: Jérôme Clerc; Michael Groll; Damir J Illich; André S Bachmann; Robert Huber; Barbara Schellenberg; Robert Dudler; Markus Kaiser
Journal: Proc Natl Acad Sci U S A Date: 2009-04-09 Impact factor: 11.205

4. Syrbactin Structural Analog TIR-199 Blocks Proteasome Activity and Induces Tumor Cell Death.

Authors: André S Bachmann; John Opoku-Ansah; Tannya R Ibarra-Rivera; Lisette P Yco; Sudhakar Ambadi; Christopher C Roberts; Chia-En A Chang; Michael C Pirrung
Journal: J Biol Chem Date: 2016-02-23 Impact factor: 5.157

Review 5. Nonribosomal peptides and polyketides of Burkholderia: new compounds potentially implicated in biocontrol and pharmaceuticals.

Authors: Qassim Esmaeel; Maude Pupin; Philippe Jacques; Valérie Leclère
Journal: Environ Sci Pollut Res Int Date: 2017-05-25 Impact factor: 4.223

6. Syrbactin proteasome inhibitor TIR-199 overcomes bortezomib chemoresistance and inhibits multiple myeloma tumor growth in vivo.

Authors: Marquicia R Pierce; Reeder M Robinson; Tannya R Ibarra-Rivera; Michael C Pirrung; Nathan G Dolloff; André S Bachmann
Journal: Leuk Res Date: 2019-11-12 Impact factor: 3.156

Glidobactins A, B and C, new antitumor antibiotics. I. Production, isolation, chemical properties and biological activity.

1. Improvement of glidobactin A production by Polyangium brachysporum.

2. N-acylation during glidobactin biosynthesis by the tridomain nonribosomal peptide synthetase module GlbF.

3. Synthetic and structural studies on syringolin A and B reveal critical determinants of selectivity and potency of proteasome inhibition.

4. Syrbactin Structural Analog TIR-199 Blocks Proteasome Activity and Induces Tumor Cell Death.

Review 5. Nonribosomal peptides and polyketides of Burkholderia: new compounds potentially implicated in biocontrol and pharmaceuticals.

6. Syrbactin proteasome inhibitor TIR-199 overcomes bortezomib chemoresistance and inhibits multiple myeloma tumor growth in vivo.

7. Burkholderia as a Source of Natural Products.

8. Production of cytotoxic glidobactins/luminmycins by Photorhabdus asymbiotica in liquid media and live crickets.

9. One-shot NMR analysis of microbial secretions identifies highly potent proteasome inhibitor.

10. Concise Chemoenzymatic Total Synthesis and Identification of Cellular Targets of Cepafungin I.