Literature DB >> 3142795

Fractionation of synaptophysin-containing vesicles from rat brain and cultured PC12 pheochromocytoma cells.

B Wiedenmann1, H Rehm, M Knierim, C M Becker.   

Abstract

Synaptophysin is a transmembrane glycoprotein of neuroendocrine vesicles. Its content and distribution in subcellular fractions from cultured PC12 cells, rat brain and bovine adrenal medulla were determined by a sensitive dot immunoassay. Synaptophysin-containing fractions appeared as monodispersed populations similar to synaptic vesicles in density and size distribution. Membranes from synaptic vesicles contained approximately 100-times more synaptophysin than chromaffin granules. In conclusion, synaptophysin is located almost exclusively in vesicles of brain and PC12 cells which are distinct from dense core granules.

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Year:  1988        PMID： 3142795     DOI： 10.1016/0014-5793(88)80342-9

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  26 in total

1.  Dp71, utrophin and beta-dystroglycan expression and distribution in PC12/L6 cell cocultures.

Authors:  Ramses Ilarraza-Lomeli; Bulmaro Cisneros-Vega; Maria de Lourdes Cervantes-Gomez; Dominique Mornet; Cecilia Montañez
Journal:  Neuroreport       Date:  2007-10-29       Impact factor: 1.837

2.  Immunocytochemical localization of synaptic proteins at vesicular organelles in PC12 cells.

Authors:  M Marxen; V Maienschein; W Volknandt; H Zimmermann
Journal:  Neurochem Res       Date:  1997-08       Impact factor: 3.996

Review 3.  Membrane composition of adrenergic large and small dense cored vesicles and of synaptic vesicles: consequences for their biogenesis.

Authors:  H Winkler
Journal:  Neurochem Res       Date:  1997-08       Impact factor: 3.996

4.  Synaptic vesicles form by budding from tubular extensions of sorting endosomes in PC12 cells.

Authors:  H de Wit; Y Lichtenstein; H J Geuze; R B Kelly; P van der Sluijs; J Klumperman
Journal:  Mol Biol Cell       Date:  1999-12       Impact factor: 4.138

5.  A distinct class of intracellular storage vesicles, identified by expression of the glucose transporter GLUT4.

Authors:  G A Herman; F Bonzelius; A M Cieutat; R B Kelly
Journal:  Proc Natl Acad Sci U S A       Date:  1994-12-20       Impact factor: 11.205

6.  Post-transcriptional regulation of synaptic vesicle protein expression and the developmental control of synaptic vesicle formation.

Authors:  C Daly; E B Ziff
Journal:  J Neurosci       Date:  1997-04-01       Impact factor: 6.167

7.  The amphicrine pancreatic cell line AR42J: a model system for combined studies on exocrine and endocrine secretion.

Authors:  S Rosewicz; E O Riecken; B Wiedenmann
Journal:  Clin Investig       Date:  1992 Mar-Apr

8.  Synaptophysin-containing microvesicles transport heat-shock protein hsp60 in insulin-secreting beta cells.

Authors:  K Brudzynski; V Martinez
Journal:  Cytotechnology       Date:  1993       Impact factor: 2.058

9.  A gamma-aminobutyric acid transporter driven by a proton pump is present in synaptic-like microvesicles of pancreatic beta cells.

Authors:  A Thomas-Reetz; J W Hell; M J During; C Walch-Solimena; R Jahn; P De Camilli
Journal:  Proc Natl Acad Sci U S A       Date:  1993-06-01       Impact factor: 11.205

10.  Development of polyclonal antibodies and evaluation of a sensitive radioimmunoassay for detection and measurement of synaptophysin.

Authors:  M Stridsberg; G Lundqvist; U Engström; E Wilander; H Su; A Gobl; K Oberg
Journal:  Acta Neuropathol       Date:  1994       Impact factor: 17.088
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