Literature DB >> 31427306

Prediagnostic Leukocyte Telomere Length and Pancreatic Cancer Survival.

Tsuyoshi Hamada1, Chen Yuan2,3, Shuji Ogino4,3,5,6, Brian M Wolpin2, Ying Bao7, Mingfeng Zhang8, Natalia Khalaf9, Ana Babic2, Vicente Morales-Oyarvide2, Barbara B Cochrane10, J Michael Gaziano11,12, Edward L Giovannucci3,7,13, Peter Kraft3,14, JoAnn E Manson3,7,11, Kimmie Ng2, Jonathan A Nowak5, Thomas E Rohan15, Howard D Sesso3,11, Meir J Stampfer3,7,13, Laufey T Amundadottir8, Charles S Fuchs16,17,18, Immaculata De Vivo3,7.   

Abstract

BACKGROUND: Leukocyte telomere length has been associated with risk of subsequent pancreatic cancer. Few prospective studies have evaluated the association of prediagnostic leukocyte telomere length with pancreatic cancer survival.
METHODS: We prospectively examined the association of prediagnostic leukocyte telomere length with overall survival (OS) time among 423 participants diagnosed with pancreatic adenocarcinoma between 1984 and 2008 within the Health Professionals Follow-up Study, Nurses' Health Study, Physicians' Health Study, and Women's Health Initiative. We measured prediagnostic leukocyte telomere length in banked blood samples using quantitative PCR. Cox proportional hazards models were used to estimate HRs for OS with adjustment for potential confounders. We also evaluated 10 SNPs at the telomerase reverse transcriptase locus.
RESULTS: Shorter prediagnostic leukocyte telomere length was associated with reduced OS among patients with pancreatic cancer (P trend = 0.04). The multivariable-adjusted HR for OS comparing the lowest with highest quintiles of leukocyte telomere length was 1.39 (95% confidence interval, 1.01-1.93), corresponding to a 3-month difference in median OS time. In an analysis excluding cases with blood collected within 2 years of cancer diagnosis, the association was moderately stronger (HR, 1.55; 95% confidence interval, 1.09-2.21; comparing the lowest with highest quintiles; P trend = 0.01). No prognostic association or effect modification for the prognostic association of prediagnostic leukocyte telomere length was noted in relation to the studied SNPs.
CONCLUSIONS: Prediagnostic leukocyte telomere length was associated with pancreatic cancer survival. IMPACT: Prediagnostic leukocyte telomere length can be a prognostic biomarker in pancreatic cancer. ©2019 American Association for Cancer Research.

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Year:  2019        PMID: 31427306      PMCID: PMC6825575          DOI: 10.1158/1055-9965.EPI-19-0577

Source DB:  PubMed          Journal:  Cancer Epidemiol Biomarkers Prev        ISSN: 1055-9965            Impact factor:   4.254


  61 in total

1.  Age-adjusted recipient pretransplantation telomere length and treatment-related mortality after hematopoietic stem cell transplantation.

Authors:  Régis Peffault de Latour; Rodrigo T Calado; Marc Busson; Jeffrey Abrams; Nadir Adoui; Marie Robin; Jérôme Larghero; Nathalie Dhedin; Alienor Xhaard; Emmanuel Clave; Dominique Charron; Antoine Toubert; Pascale Loiseau; Gérard Socié; Neal S Young
Journal:  Blood       Date:  2012-09-04       Impact factor: 22.113

2.  Circulating Metabolites and Survival Among Patients With Pancreatic Cancer.

Authors:  Chen Yuan; Clary B Clish; Chen Wu; Jared R Mayers; Peter Kraft; Mary K Townsend; Mingfeng Zhang; Shelley S Tworoger; Ying Bao; Zhi Rong Qian; Douglas A Rubinson; Kimmie Ng; Edward L Giovannucci; Shuji Ogino; Meir J Stampfer; John Michael Gaziano; Jing Ma; Howard D Sesso; Garnet L Anderson; Barbara B Cochrane; JoAnn E Manson; Margaret E Torrence; Alec C Kimmelman; Laufey T Amundadottir; Matthew G Vander Heiden; Charles S Fuchs; Brian M Wolpin
Journal:  J Natl Cancer Inst       Date:  2016-01-11       Impact factor: 13.506

3.  Prediagnostic Plasma 25-Hydroxyvitamin D and Pancreatic Cancer Survival.

Authors:  Chen Yuan; Zhi Rong Qian; Ana Babic; Vicente Morales-Oyarvide; Douglas A Rubinson; Peter Kraft; Kimmie Ng; Ying Bao; Edward L Giovannucci; Shuji Ogino; Meir J Stampfer; John Michael Gaziano; Howard D Sesso; Julie E Buring; Barbara B Cochrane; Rowan T Chlebowski; Linda G Snetselaar; JoAnn E Manson; Charles S Fuchs; Brian M Wolpin
Journal:  J Clin Oncol       Date:  2016-06-20       Impact factor: 44.544

4.  Meta-analysis in clinical trials.

Authors:  R DerSimonian; N Laird
Journal:  Control Clin Trials       Date:  1986-09

5.  The patterns and dynamics of genomic instability in metastatic pancreatic cancer.

Authors:  Peter J Campbell; Shinichi Yachida; Laura J Mudie; Philip J Stephens; Erin D Pleasance; Lucy A Stebbings; Laura A Morsberger; Calli Latimer; Stuart McLaren; Meng-Lay Lin; David J McBride; Ignacio Varela; Serena A Nik-Zainal; Catherine Leroy; Mingming Jia; Andrew Menzies; Adam P Butler; Jon W Teague; Constance A Griffin; John Burton; Harold Swerdlow; Michael A Quail; Michael R Stratton; Christine Iacobuzio-Donahue; P Andrew Futreal
Journal:  Nature       Date:  2010-10-28       Impact factor: 49.962

6.  Synchrony of telomere length among hematopoietic cells.

Authors:  Masayuki Kimura; Yair Gazitt; Xiaojian Cao; Xiangru Zhao; Peter M Lansdorp; Abraham Aviv
Journal:  Exp Hematol       Date:  2010-06-25       Impact factor: 3.084

7.  Adjusted survival curve estimation using covariates.

Authors:  R W Makuch
Journal:  J Chronic Dis       Date:  1982

Review 8.  Telomere Length and Breast Cancer Prognosis: A Systematic Review.

Authors:  Kaoutar Ennour-Idrissi; Elizabeth Maunsell; Caroline Diorio
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2016-09-27       Impact factor: 4.254

9.  Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development.

Authors:  Jared R Mayers; Chen Wu; Clary B Clish; Peter Kraft; Margaret E Torrence; Brian P Fiske; Chen Yuan; Ying Bao; Mary K Townsend; Shelley S Tworoger; Shawn M Davidson; Thales Papagiannakopoulos; Annan Yang; Talya L Dayton; Shuji Ogino; Meir J Stampfer; Edward L Giovannucci; Zhi Rong Qian; Douglas A Rubinson; Jing Ma; Howard D Sesso; John Michael Gaziano; Barbara B Cochrane; Simin Liu; Jean Wactawski-Wende; JoAnn E Manson; Michael N Pollak; Alec C Kimmelman; Amanda Souza; Kerry Pierce; Thomas J Wang; Robert E Gerszten; Charles S Fuchs; Matthew G Vander Heiden; Brian M Wolpin
Journal:  Nat Med       Date:  2014-09-28       Impact factor: 53.440

10.  Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.

Authors:  Brian M Wolpin; Cosmeri Rizzato; Peter Kraft; Charles Kooperberg; Gloria M Petersen; Zhaoming Wang; Alan A Arslan; Laura Beane-Freeman; Paige M Bracci; Julie Buring; Federico Canzian; Eric J Duell; Steven Gallinger; Graham G Giles; Gary E Goodman; Phyllis J Goodman; Eric J Jacobs; Aruna Kamineni; Alison P Klein; Laurence N Kolonel; Matthew H Kulke; Donghui Li; Núria Malats; Sara H Olson; Harvey A Risch; Howard D Sesso; Kala Visvanathan; Emily White; Wei Zheng; Christian C Abnet; Demetrius Albanes; Gabriella Andreotti; Melissa A Austin; Richard Barfield; Daniela Basso; Sonja I Berndt; Marie-Christine Boutron-Ruault; Michelle Brotzman; Markus W Büchler; H Bas Bueno-de-Mesquita; Peter Bugert; Laurie Burdette; Daniele Campa; Neil E Caporaso; Gabriele Capurso; Charles Chung; Michelle Cotterchio; Eithne Costello; Joanne Elena; Niccola Funel; J Michael Gaziano; Nathalia A Giese; Edward L Giovannucci; Michael Goggins; Megan J Gorman; Myron Gross; Christopher A Haiman; Manal Hassan; Kathy J Helzlsouer; Brian E Henderson; Elizabeth A Holly; Nan Hu; David J Hunter; Federico Innocenti; Mazda Jenab; Rudolf Kaaks; Timothy J Key; Kay-Tee Khaw; Eric A Klein; Manolis Kogevinas; Vittorio Krogh; Juozas Kupcinskas; Robert C Kurtz; Andrea LaCroix; Maria T Landi; Stefano Landi; Loic Le Marchand; Andrea Mambrini; Satu Mannisto; Roger L Milne; Yusuke Nakamura; Ann L Oberg; Kouros Owzar; Alpa V Patel; Petra H M Peeters; Ulrike Peters; Raffaele Pezzilli; Ada Piepoli; Miquel Porta; Francisco X Real; Elio Riboli; Nathaniel Rothman; Aldo Scarpa; Xiao-Ou Shu; Debra T Silverman; Pavel Soucek; Malin Sund; Renata Talar-Wojnarowska; Philip R Taylor; George E Theodoropoulos; Mark Thornquist; Anne Tjønneland; Geoffrey S Tobias; Dimitrios Trichopoulos; Pavel Vodicka; Jean Wactawski-Wende; Nicolas Wentzensen; Chen Wu; Herbert Yu; Kai Yu; Anne Zeleniuch-Jacquotte; Robert Hoover; Patricia Hartge; Charles Fuchs; Stephen J Chanock; Rachael S Stolzenberg-Solomon; Laufey T Amundadottir
Journal:  Nat Genet       Date:  2014-08-03       Impact factor: 41.307

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2.  Race Differences in Telomere Length in Benign Prostate Biopsies and Subsequent Risk of Prostate Cancer.

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3.  Association of circulating leukocyte telomere length with survival in patients with colorectal cancer.

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4.  Circulating lipids and glioma risk: results from the UK Biobank, Nurses' Health Study, and Health Professionals Follow-Up Study.

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5.  Shorter Treatment-Naïve Leukocyte Telomere Length is Associated with Poorer Overall Survival of Patients with Pancreatic Ductal Adenocarcinoma.

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