Literature DB >> 31427298

Extremely Low Hit Rate in a Diverse Chemical Drug Screen Targeting Mycobacterium abscessus.

Jakob J Malin1,2, Sandra Winter1,2, Edeltraud van Gumpel1,2, Georg Plum3, Jan Rybniker4,2,5.   

Abstract

Entities:  

Keywords:  Mycobacterium abscessuszzm321990; NTM; drug discovery; drug screening; emerging pathogens; hit rate

Mesh：

Substances：

Year:  2019        PMID： 31427298      PMCID： PMC6811439          DOI： 10.1128/AAC.01008-19

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


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  27 in total

1.  In Vitro Activity of New Tetracycline Analogs Omadacycline and Eravacycline against Drug-Resistant Clinical Isolates of Mycobacterium abscessus.

Authors:  Amit Kaushik; Nicole C Ammerman; Olumide Martins; Nicole M Parrish; Eric L Nuermberger
Journal:  Antimicrob Agents Chemother       Date:  2019-05-24       Impact factor: 5.191

2.  Differential gene expression in response to exposure to antimycobacterial agents and other stress conditions among seven Mycobacterium tuberculosis whiB-like genes.

Authors:  Deborah E Geiman; Tirumalai R Raghunand; Nisheeth Agarwal; William R Bishai
Journal:  Antimicrob Agents Chemother       Date:  2006-08       Impact factor: 5.191

Review 3.  Perspective: Challenges and opportunities in TB drug discovery from phenotypic screening.

Authors:  Ujjini H Manjunatha; Paul W Smith
Journal:  Bioorg Med Chem       Date:  2014-12-24       Impact factor: 3.641

Review 4.  Novel and revisited approaches in antituberculosis drug discovery.

Authors:  Jennifer Herrmann; Jan Rybniker; Rolf Müller
Journal:  Curr Opin Biotechnol       Date:  2017-04-17       Impact factor: 9.740

Review 5.  Mycobacterium abscessus: a new antibiotic nightmare.

Authors:  Rachid Nessar; Emmanuelle Cambau; Jean Marc Reyrat; Alan Murray; Brigitte Gicquel
Journal:  J Antimicrob Chemother       Date:  2012-01-30       Impact factor: 5.790

Review 6.  WhiB7, a transcriptional activator that coordinates physiology with intrinsic drug resistance in Mycobacterium tuberculosis.

Authors:  Ján Burian; Santiago Ramón-García; Charles G Howes; Charles J Thompson
Journal:  Expert Rev Anti Infect Ther       Date:  2012-09       Impact factor: 5.091

Review 7.  NTM drug discovery: status, gaps and the way forward.

Authors:  Mu-Lu Wu; Dinah B Aziz; Véronique Dartois; Thomas Dick
Journal:  Drug Discov Today       Date:  2018-04-07       Impact factor: 7.851

8.  In Vitro and Intracellular Activity of Imipenem Combined with Rifabutin and Avibactam against Mycobacterium abscessus.

Authors:  Eva Le Run; Michel Arthur; Jean-Luc Mainardi
Journal:  Antimicrob Agents Chemother       Date:  2018-07-27       Impact factor: 5.191

Review 9.  Tuberculosis drug discovery in the post-post-genomic era.

Authors:  Benoit Lechartier; Jan Rybniker; Alimuddin Zumla; Stewart T Cole
Journal:  EMBO Mol Med       Date:  2014-01-08       Impact factor: 12.137

10.  Rifabutin Is Active against Mycobacterium abscessus Complex.

Authors:  Dinah Binte Aziz; Jian Liang Low; Mu-Lu Wu; Martin Gengenbacher; Jeanette W P Teo; Véronique Dartois; Thomas Dick
Journal:  Antimicrob Agents Chemother       Date:  2017-05-24       Impact factor: 5.191
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  5 in total

1.  Rifabutin Is Inactivated by Mycobacterium abscessus Arr.

Authors:  Daniel Schäfle; Petra Selchow; Barbara Borer; Michael Meuli; Anna Rominski; Bettina Schulthess; Peter Sander
Journal:  Antimicrob Agents Chemother       Date:  2021-02-17       Impact factor: 5.191

2.  Mycobacterium abscessus drug discovery using machine learning.

Authors:  Alan A Schmalstig; Kimberley M Zorn; Sebastian Murcia; Andrew Robinson; Svetlana Savina; Elena Komarova; Vadim Makarov; Miriam Braunstein; Sean Ekins
Journal:  Tuberculosis (Edinb)       Date:  2022-01-20       Impact factor: 3.131

3.  A Screening of the MMV Pandemic Response Box Reveals Epetraborole as a New Potent Inhibitor against Mycobacterium abscessus.

Authors:  Taeho Kim; Bui-Thi-Bich Hanh; Boeun Heo; Nguyenthanh Quang; Yujin Park; Jihyeon Shin; Seunghyeon Jeon; June-Woo Park; Kirandeep Samby; Jichan Jang
Journal:  Int J Mol Sci       Date:  2021-05-31       Impact factor: 5.923

4.  Thiostrepton: A Novel Therapeutic Drug Candidate for Mycobacterium abscessus Infection.

Authors:  Tae Ho Kim; Bui Thi Bich Hanh; Guehye Kim; Da-Gyum Lee; June-Woo Park; So Eui Lee; Jae-Sung Kim; Byoung Soo Kim; Sungweon Ryoo; Eun-Kyeong Jo; Jichan Jang
Journal:  Molecules       Date:  2019-12-10       Impact factor: 4.411

5.  Etamycin as a Novel Mycobacterium abscessus Inhibitor.

Authors:  Bui Thi Bich Hanh; Tae Ho Kim; June-Woo Park; Da-Gyum Lee; Jae-Sung Kim; Young Eun Du; Chul-Su Yang; Dong-Chan Oh; Jichan Jang
Journal:  Int J Mol Sci       Date:  2020-09-21       Impact factor: 5.923
  5 in total

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