Rajesh Rajput1, Parul Ahlawat2. 1. Department of Endocrinology & Medicine Unit IV, Pt. B D Sharma Postgraduate Institute of Medical Sciences, Rohtak, Haryana, India. Electronic address: drrajeshrajput@outlook.com. 2. Department of Endocrinology & Medicine Unit IV, Pt. B D Sharma Postgraduate Institute of Medical Sciences, Rohtak, Haryana, India.
Abstract
BACKGROUD AND AIMS: Various studies have evaluated the prevalence of non-alcoholic fatty liver disease (NAFLD) in patients with diabetes but few studies on prevalence of NAFLD in prediabetes have been performed so far. The present study aimed to evaluate the prevalence and predictors of NAFLD in prediabetics. MATERIAL AND METHODS: In this cross-sectional study, 100 diagnosed cases of Prediabetes were compared with 100 normoglycemic people after random selection from OPD for NAFLD by using various biochemical parameters and ultrasonography. RESULTS: Among 100 prediabetic cases, IFG was present in 28%, IGT in 26% and both were impaired in 46%. FPG, 2 Hour glucose post OGTT, diastolic blood pressure, weight, BMI, waist circumference, waist hip ratio, waist height ratio was significantly more in prediabetics as compared to controls. On USG, prevalence of NAFLD was more in prediabetics (59%) as compared to controls (26%) with p value =<0.001. Grade 1 fatty liver was present in 37% (n = 37) prediabetics as compare to 22% (n = 22) controls and Grade 2 fatty liver was present in 22% (n = 22) cases as compare to 4% (n = 4) controls with p value < 0.001. SGOT, SGPT, GGT, ALP, UA, TG were significantly higher in prediabetics as compared to controls. GGT and WC are best predictor of NAFLD in pre-diabetes with adjusted odd's ratio of 6.604 and 6.589 respectively. CONCLUSION: To conclude with, prevalence of NAFLD is substantially more in prediabetic patients as compared to normoglycemic individuals and elevated WC and GGT were the best predictor of underlying NAFLD among prediabetic individuals.
BACKGROUD AND AIMS: Various studies have evaluated the prevalence of non-alcoholic fatty liver disease (NAFLD) in patients with diabetes but few studies on prevalence of NAFLD in prediabetes have been performed so far. The present study aimed to evaluate the prevalence and predictors of NAFLD in prediabetics. MATERIAL AND METHODS: In this cross-sectional study, 100 diagnosed cases of Prediabetes were compared with 100 normoglycemic people after random selection from OPD for NAFLD by using various biochemical parameters and ultrasonography. RESULTS: Among 100 prediabetic cases, IFG was present in 28%, IGT in 26% and both were impaired in 46%. FPG, 2 Hour glucose post OGTT, diastolic blood pressure, weight, BMI, waist circumference, waist hip ratio, waist height ratio was significantly more in prediabetics as compared to controls. On USG, prevalence of NAFLD was more in prediabetics (59%) as compared to controls (26%) with p value =<0.001. Grade 1 fatty liver was present in 37% (n = 37) prediabetics as compare to 22% (n = 22) controls and Grade 2 fatty liver was present in 22% (n = 22) cases as compare to 4% (n = 4) controls with p value < 0.001. SGOT, SGPT, GGT, ALP, UA, TG were significantly higher in prediabetics as compared to controls. GGT and WC are best predictor of NAFLD in pre-diabetes with adjusted odd's ratio of 6.604 and 6.589 respectively. CONCLUSION: To conclude with, prevalence of NAFLD is substantially more in prediabetic patients as compared to normoglycemic individuals and elevated WC and GGT were the best predictor of underlying NAFLD among prediabetic individuals.
Authors: Joshua B Gross; Dennis A Sun; Brian M Carlson; Sivan Brodo-Abo; Meredith E Protas Journal: Genes (Basel) Date: 2019-12-29 Impact factor: 4.096