| Literature DB >> 31425266 |
John M Toomasian1, Mark M P Jeakle1, Mark W Langley1, Clinton J Poling1, Gergely Lautner2, Orsolya Lautner-Csorba2, Mark M Meyerhoff2, Ben Jamin D Carr1, Alvaro Rojas-Pena1, Jonathan W Haft3, Robert H Bartlett1.
Abstract
Cardiopulmonary bypass causes a systemic inflammatory response reaction that may contribute to postoperative complications. One cause relates to the air/blood interface from the extracorporeal circuit. The modulatory effects of blending nitric oxide (NO) gas into the ventilation/sweep gas of the membrane lung was studied in a porcine model of air-induced inflammation in which NO gas was added and compared with controls with or without an air/blood interface. Healthy swine were supported on partial bypass under four different test conditions. Group 1: no air exposure, group 2: air alone, group 3: air plus 50 ppm NO, and group 4: air plus 500 ppm NO. The NO gas was blended into the ventilation/sweep site of the membrane lung. The platelets and leucocytes were activated by air alone. Addition of NO to the sweep gas attenuated the inflammatory response created by the air/blood interface in this model.Entities:
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Year: 2020 PMID： 31425266 PMCID： PMC7024006 DOI： 10.1097/MAT.0000000000001057
Source DB: PubMed Journal: ASAIO J ISSN： 1058-2916 Impact factor: 3.826