Literature DB >> 3142484

Cyclosporin A augments vasoconstrictor-induced rise in intracellular free calcium in rat renal mesangial cells.

J Pfeilschifter1.   

Abstract

Pretreatment of rat renal mesangial cells with the immunosuppressive drug cyclosporin A caused a dose-dependent increase in the angiotensin II, [Arg8]vasopressin and noradrenalin-stimulated rise in intracellular free calcium as measured with quin 2. Cyclosporin A had no significant effect on basal cytosolic free calcium. However, cyclosporin A increased the basal 45Ca2+ influx. This stimulated 45Ca2+ influx was not blocked by nifedipine (10(-6) M). Cyclosporin A also augmented the angiotensin II, [Arg8]vasopressin and noradrenalin-stimulated efflux of 45Ca2+ from mesangial cells. These results suggest that cyclosporin A stimulates transmembrane Ca2+ influx in mesangial cells and also augments the vasoconstrictor-induced increases in cytosolic free calcium.

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Year:  1988        PMID： 3142484     DOI： 10.1016/0006-2952(88)90117-7

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


  8 in total

1.  Theophylline: a new concept of nephroprotection in acute cyclosporin A nephrotoxicity?

Authors:  P M Rob; J Fandrey; W Jelkmann
Journal:  Klin Wochenschr       Date:  1989-06-15

Review 2.  The pathophysiology of Sandimmune (cyclosporine) in man and animals.

Authors:  J Mason
Journal:  Pediatr Nephrol       Date:  1990-09       Impact factor: 3.714

3.  [Studies on cultured rat mesangial cells using cyclosporin A and magnesium--is magnesium nephroprotective in cyclosporin A therapy?].

Authors:  P M Rob; J Fandrey
Journal:  Klin Wochenschr       Date:  1990-08-17

4.  Effects of cyclosporin and FK-506 on glomerular mesangial cells. Evidence for direct inhibition of thromboxane synthase by low cyclosporin concentrations.

Authors:  H H Radeke; S Kuster; V Kaever; K Resch
Journal:  Eur J Clin Pharmacol       Date:  1993       Impact factor: 2.953

5.  Cyclic AMP mimics, but does not mediate, interleukin-1- and tumour-necrosis-factor-stimulated phospholipase A2 secretion from rat renal mesangial cells.

Authors:  J Pfeilschifter; J Leighton; W Pignat; F Märki; K Vosbeck
Journal:  Biochem J       Date:  1991-01-01       Impact factor: 3.857

Review 6.  Cyclosporin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in immunoregulatory disorders.

Authors:  Diana Faulds; Karen L Goa; Paul Benfield
Journal:  Drugs       Date:  1993-06       Impact factor: 9.546

7.  Cellular signaling by cyclosporine A in contractile cells: interactions with atrial natriuretic peptide.

Authors:  H Meyer-Lehnert; D Bokemeyer; U Friedrichs; S Drechsler; H J Kramer
Journal:  Clin Investig       Date:  1993-02

8.  Effect of cyclosporin A and analogues on cytosolic calcium and vasoconstriction: possible lack of relationship to immunosuppressive activity.

Authors:  A Lo Russo; A C Passaquin; P André; M Skutella; U T Rüegg
Journal:  Br J Pharmacol       Date:  1996-06       Impact factor: 8.739
  8 in total

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